Asymmetric synthesis of arylalanines via asymmetric aza-darzens (ADZ) reaction
Maguire, N.E., McLaren, A.B. and Sweeney, J.B. (2003) Asymmetric synthesis of arylalanines via asymmetric aza-darzens (ADZ) reaction. Synlett, 12. pp. 1898-1900. ISSN 0936-5214
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To link to this article DOI: 10.1055/s-2003-41470
(R)-3-Arylalanines may be prepared in high enantiomeric purity from N-dpp imines by a four-step reaction sequence involving asymmetric aza-Darzens reaction, dephosphinylation, hydrogenolysis and hydrolysis. The amino acids thus obtained were of >95% enantiomeric purity.