Accessibility navigation


Carbohydrate-based therapeutics

Osborn, H.M.I., Evans, P.G., Gemmell, N. and Osborne, S.D. (2004) Carbohydrate-based therapeutics. Journal of Pharmacy and Pharmacology, 56 (6). pp. 691-702. ISSN 0022-3573

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1211/0022357023619

Abstract/Summary

In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11540
Uncontrolled Keywords:PHASE OLIGOSACCHARIDE SYNTHESIS, GLYCOSIDASE INHIBITORS, CAPSULAR, POLYSACCHARIDE, ADVANCED MALIGNANCIES, CLINICAL-APPLICATIONS, ANTIINFECTIVE AGENTS, TUMOR-METASTASIS, ANTICANCER DRUGS, CANCER, VACCINES, CELLS

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation