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Nutrigenetics and CVD: what does the future hold?

Lovegrove, J.A. and Gitau, R. (2008) Nutrigenetics and CVD: what does the future hold? Proceedings of the Nutrition Society, 67. pp. 206-213. ISSN 0029-6651

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To link to this item DOI: 10.1017/s0029665108007040

Abstract/Summary

CVD is a common killer in both the Western world and the developing world. It is a multifactorial disease that is influenced by many environmental and genetic factors. Although public health advice to date has been principally in the form of prescribed population-based recommendations, this approach has been surprisingly unsuccessful in reducing CVD risk. This outcome may be explained, in part, by the extreme variability in response to dietary manipulations between individuals and interactions between diet and an individual's genetic background, which are defined by the term 'nutrigenetics'. The shift towards personalised nutritional advice is a very attractive proposition. In principle an individual could be genotyped and given dietary advice specifically tailored to their genetic make-up. Evidence-based research into interactions between fixed genetic variants, nutrient intake and biomarkers of CVD risk is increasing, but still limited. The present paper will review the evidence for interactions between dietary fat and three common polymorphisms in the apoE, apoAI and PPAR gamma genes. Increased knowledge of how these and other genes influence dietary response should increase the understanding of personalised nutrition. While targeted dietary advice may have considerable potential for reducing CVD risk, the ethical issues associated with its routine use need careful consideration.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:13194
Uncontrolled Keywords:nutrigenetics, apoE, apoAI and PPAR gamma polymorphisms, CVD risk, dietary fat
Additional Information:Symposium on Diet and Cancer/Diet and Bone Health/Diet and CVD University of Ulster, Coleraine, IRELAND 16-19 JUL 2008

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