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Mucoadhesive and elastic films based on blends of chitosan and hydroxyethylcellulose

Luo, K., Yin, J.B., Khutoryanskaya, O.V. and Khutoryanskiy, V.V. (2008) Mucoadhesive and elastic films based on blends of chitosan and hydroxyethylcellulose. Macromolecular Bioscience, 8 (2). pp. 184-192. ISSN 1616-5187

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To link to this article DOI: 10.1002/mabi.200700185

Abstract/Summary

Mucoadhesive polymeric films have been prepared based on blends of chitosan and hydroxyethylcellulose. The blends have been characterized by IR spectroscopy, DSC, WAXD, TGA, SEM, and mechanical testing. It is demonstrated that the mechanical properties of chitosan are improved significantly upon blending with hydroxyethylcellulose. An increase in hydroxyethylcellulose content in the blends makes the materials more elastic. The thermal treatment of the blends at 100 degrees C leads to partial cross-linking of the polymers and formation of water-insoluble but swellable materials. The adhesion of the films towards porcine buccal mucosa decreases with increasing hydroxyethylcellulose content in the blends.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13697
Uncontrolled Keywords:blends, buccal films, cellulose ether, chitosan, miscibility, mucoadhesion, PHARMACEUTICAL APPLICATIONS, POLY(ETHYLENE OXIDE), POLY(ACRYLIC ACID), HYDROPHILIC FILMS, POLYMER BLENDS, MISCIBILITY, DERIVATIVES, PERFORMANCE, COLLAGEN

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