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Lys-gamma3-MSH: a global regulator of hormone sensitive lipase activity?

Bicknell, K. A., Harmer, S. C., Yiangson, S., Lockwood, W. and Bicknell, A. B. (2009) Lys-gamma3-MSH: a global regulator of hormone sensitive lipase activity? Molecular and Cellular Endocrinology , 300 (1-2). pp. 71-76. ISSN 0303-7207

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To link to this article DOI: 10.1016/j.mce.2008.09.032

Abstract/Summary

Gamma-melanocyte stimulating hormone (gamma-MSH) is a peptide derived from the ACTH precursor, pro-opiomelanocortin (POMC), and belongs to a family of peptides called the melanocortins that also comprises alpha- and beta-MSH. Although conserved in tetrapods, the biological role of gamma-MSH remains largely undefined. It has been demonstrated previously that gamma-MSH is involved in the regulating the activity of hormone sensitive lipase (HSL) activity in the adrenal and more recently, in the adipocyte. It has been shown also to have effects on the cardiovascular and renal systems. This short review will provide a brief overview of the role of gamma-MSH in the adrenal and the more recent report that it can also regulate HSL function in the adipocyte. We also present some preliminary data purporting a direct role for Lys-gamma(3)-MSH in the regulation of HSL phosphorylation in the heart. Taken together these data suggest that gamma-MSH peptides might play a more widespread role in lipid and cholesterol utilization.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:1986
Uncontrolled Keywords:Adrenal; Adipocyte; Gamma-MSH; Heart; POMC; Steroidogenesis
Additional Information:Conference Information: 13th Conference on the Adrenal Cortex (Adrenal 2008) Burlingame, CA, JUN 11-14, 2008
Publisher:Elsevier

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