Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocksTools  Madine, J., Davies, H. A., Shaw, C., Hamley, I. W. and Middleton, D. A. (2012) Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks. Chemical Communications, 48. pp. 2976-2978. ISSN 1359-7345
To link to this article DOI: 10.1039/C2CC17118J Abstract/SummaryThe peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.
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