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Towards a model-based integration of co-registered electroencephalography/functional magnetic resonance imaging data with realistic neural population meshes

Bojak, I., Oostendorp, T. F., Reid, A. T. and Kotter, R. (2011) Towards a model-based integration of co-registered electroencephalography/functional magnetic resonance imaging data with realistic neural population meshes. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 369 (1952). pp. 3785-3801. ISSN 1364-503X

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To link to this item DOI: 10.1098/rsta.2011.0080

Abstract/Summary

Brain activity can be measured with several non-invasive neuroimaging modalities, but each modality has inherent limitations with respect to resolution, contrast and interpretability. It is hoped that multimodal integration will address these limitations by using the complementary features of already available data. However, purely statistical integration can prove problematic owing to the disparate signal sources. As an alternative, we propose here an advanced neural population model implemented on an anatomically sound cortical mesh with freely adjustable connectivity, which features proper signal expression through a realistic head model for the electroencephalogram (EEG), as well as a haemodynamic model for functional magnetic resonance imaging based on blood oxygen level dependent contrast (fMRI BOLD). It hence allows simultaneous and realistic predictions of EEG and fMRI BOLD from the same underlying model of neural activity. As proof of principle, we investigate here the influence on simulated brain activity of strengthening visual connectivity. In the future we plan to fit multimodal data with this neural population model. This promises novel, model-based insights into the brain's activity in sleep, rest and task conditions.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
No Reading authors. Back catalogue items
ID Code:32503
Uncontrolled Keywords:neural population model, multimodal integration, simultaneous EEG and fMRI BOLD, brain dynamics, cortical connectivity, mean-field model
Additional Information:The full text of this article is freely available via PMC using the link supplied in Related URLs
Publisher:Royal Society Publishing

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