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SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex

McCabe, C., Mishor, Z., Filippini, N., Cowen, P. J., Taylor, M. J. and Harmer, C. J. (2011) SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex. Molecular Psychiatry, 16 (6). pp. 592-594. ISSN 1476-5578

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To link to this item DOI: 10.1038/mp.2010.138

Abstract/Summary

Recent evidence suggests that an area in the dorsal medial prefrontal cortex (dorsal nexus) shows dramatic increases in connectivity across a network of brain regions in depressed patients during the resting state;1 this increase in connectivity is suggested to represent hotwiring of areas involved in disparate cognitive and emotional functions.1, 2, 3 Sheline et al.1 concluded that antidepressant action may involve normalisation of the elevated resting state functional connectivity seen in depressed patients. However, the effects of conventional pharmacotherapy for depression on this resting state functional connectivity is not known and the effects of antidepressant treatment in depressed patients may be confounded by change in symptoms following treatment.

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
ID Code:33176
Publisher:Nature Publishing Group

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