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Theory and generalization of Monte Carlo models of the BOLD signal source

Martindale, J., Kennerley, A. J., Johnston, D., Zheng, Y. and Mayhew, J. E. (2008) Theory and generalization of Monte Carlo models of the BOLD signal source. Magnetic Resonance in Medicine, 59 (3). pp. 607-618. ISSN 1522-2594

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To link to this item DOI: 10.1002/mrm.21512

Abstract/Summary

The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra- and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look-up-table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics. Magn Reson Med, 2008. © 2008 Wiley-Liss, Inc.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Department of Bio-Engineering
ID Code:33482
Uncontrolled Keywords:Monte Carlo simulations; biophysical model; BOLD; hemodynamics; fMRI
Publisher:Wiley

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