Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazolesSmith, C. D. and Greaney, M. F. (2013) Zinc mediated azide-alkyne ligation to 1,5- and 1,4,5-substituted 1,2,3-triazoles. Organic Letters, 15 (18). pp. 4826-4829. ISSN 1523-7060
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1021/ol402225d Abstract/SummaryA mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy.
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