Accessibility navigation


Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents

Chuang, J.-Y., Whitaker, K., Murray, G. K., Elliott, R., Hagan, C. C., Graham, J. M. E., Ooi, C., Tait, R., Holt, R. J., van Nieuwenhuizen, A. O., Reynolds, S., Wilkinson, P. O., Bullmore, E. T., Lennox, B. R., Sahakian, B. J., Goodyer, I. and Suckling, J. (2016) Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents. Journal of Affective Disorders, 189. pp. 54-61. ISSN 0165-0327

[img]
Preview
Text (Open Access) - Published Version
· Available under License Creative Commons Attribution.
· Please see our End User Agreement before downloading.

680kB
[img]
Preview
Text (Open Access) - Accepted Version
· Available under License Creative Commons Attribution.
· Please see our End User Agreement before downloading.

855kB

To link to this item DOI: 10.1016/j.jad.2015.09.008

Abstract/Summary

AbstractBackground Depression in adolescence is debilitating with high recurrence in adulthood, yet its pathophysiological mechanism remains enigmatic. To examine the interaction between emotion, cognition and treatment, functional brain responses to sad and happy distractors in an affective go/no-go task were explored before and after Cognitive Behavioural Therapy (CBT) in depressed female adolescents, and healthy participants. Methods Eighty-two Depressed and 24 healthy female adolescents, aged 12 to 17 years, performed a functional magnetic resonance imaging (fMRI) affective go/no-go task at baseline. Participants were instructed to withhold their responses upon seeing happy or sad words. Among these participants, 13 patients had CBT over approximately 30 weeks. These participants and 20 matched controls then repeated the task. Results At baseline, increased activation in response to happy relative to neutral distractors was observed in the orbitofrontal cortex in depressed patients which was normalized after CBT. No significant group differences were found behaviourally or in brain activation in response to sad distractors. Improvements in symptoms (mean: 9.31, 95% CI: 5.35-13.27) were related at trend-level to activation changes in orbitofrontal cortex. Limitations In the follow-up section, a limited number of post-CBT patients were recruited. Conclusions To our knowledge, this is the first fMRI study addressing the effect of CBT in adolescent depression. Although a bias toward negative information is widely accepted as a hallmark of depression, aberrant brain hyperactivity to positive distractors was found and normalised after CBT. Research, assessment and treatment focused on positive stimuli could be a future consideration. Moreover, a pathophysiological mechanism distinct from adult depression may be suggested and awaits further exploration.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Charlie Waller Institute
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Anxiety and Depression in Young People (AnDY)
ID Code:42922
Uncontrolled Keywords:Adolescent depression Functional magnetic resonance imaging Cognitive behaviour therapy Positive stimuli
Publisher:Elsevier

Downloads

Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation