Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylationUra, S., Pollitt, A. Y., Veltman, D. M., Morrice, N. A., Machesky, L. M. and Insall, R. H. (2012) Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology, 22 (7). pp. 553-561. ISSN 0960-9822
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1016/j.cub.2012.02.020 Abstract/SummaryRegulated dephosphorylation of a fraction of the cellular SCAR pool is a key step in SCAR activation during pseudopod growth. Phosphorylation increases autoinhibition of the intact complex. Dephosphorylation weakens this interaction and facilitates SCAR activation but also destabilizes the protein. We show that SCAR is specifically dephosphorylated in pseudopods, increasing activation by Rac and lipids and supporting positive feedback of pseudopod growth.
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