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Peptide based hydrogels for cancer drug release: modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating D-amino acid residue(s)

Basu, K., Baral, A., Basak, S., Dehsorkhi, A., Nanda, J., Bhunia, D., Ghosh, S., Castelletto, V., Hamley, I. W. and Banerjee, A. (2016) Peptide based hydrogels for cancer drug release: modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating D-amino acid residue(s). Chemical Communications, 52 (28). pp. 5045-5048. ISSN 1359-7345

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To link to this item DOI: 10.1039/c6cc01744d

Abstract/Summary

Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating D-amino acid residues, indicating their potential use for drug delivery in the future.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:64084
Publisher:The Royal Society of Chemistry

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