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Ubiquitin sets the timer: impacts on aging and longevity

Kevei, E. ORCID: https://orcid.org/0000-0002-0560-9208 and Hoppe, T. (2014) Ubiquitin sets the timer: impacts on aging and longevity. Nature structural & molecular biology, 21 (4). pp. 290-292. ISSN 1545-9985

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To link to this item DOI: 10.1038/nsmb.2806

Abstract/Summary

Protein homeostasis is essential for cellular function, organismal growth and viability. Damaged and aggregated proteins are turned over by two major proteolytic routes of the cellular quality-control pathways: the ubiquitin-proteasome system and autophagy. For both these pathways, ubiquitination provides the recognition signal for substrate selection. This Commentary discusses how ubiquitin-dependent proteolytic pathways are coordinated with stress- and aging-induced signals.

Item Type:Article
Refereed:No
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:65858
Publisher:Nature Publishing Group

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