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Decorin regulates endothelial cell-matrix interactions during angiogenesis

Fiedler, L. and Eble, J. A. (2009) Decorin regulates endothelial cell-matrix interactions during angiogenesis. Cell Adhesion & Migration, 3 (1). pp. 3-6. ISSN 1933-6918

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To link to this item DOI: 10.4161/cam.3.1.7275

Abstract/Summary

Interactions between endothelial cells and the surrounding extracellular matrix are continuously adapted during angiogenesis, from early sprouting through to lumen formation and vessel maturation. Regulated control of these interactions is crucial to sustain normal responses in this rapidly changing environment, and dysfunctional endothelial cell behaviour results in angiogenic disorders. The proteoglycan decorin, an extracellular matrix component, is upregulated during angiogenesis. While it was shown previously that the absence of decorin leads to dysregulated angiogenesis in vivo, the molecular mechanisms were not clear. These abnormal endothelial cell responses have been attributed to indirect effects of decorin; however, our recent data provides evidence that decorin directly regulates endothelial cell-matrix interactions. This data will be discussed in conjunction with findings from previous studies, to better understand the role of this proteoglycan in angiogenesis.

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:68798
Publisher:Taylor & Francis

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