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Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: data from the European Food4Me Study

Albani, V., Celis-Morales, C., O'Donovan, C. B., Walsh, M. C., Woolhead, C., Forster, H., Fallaize, R., Macready, A. L., Marsaux, C. F.M., Navas-Carretero, S., San-Cristoba, R., Kolossa, S., Mavrogianni, C., Lambrinou, C. P., Moschonis, G., Godlewska, M., Surwillo, A., Traczyk, I., Gundersen, T. E., Drevon, C. A. , Daniel, H., Manios, Y., Martinez, J. A., Saris, W. H.M., Lovegrove, J. A., Gibney, M. J., Gibney, E. R., Mathers, J. C., Adamson, A. J. and Brennan, L. (2017) Within-person reproducibility and sensitivity to dietary change of C15:0 and C17:0 levels in dried blood spots: data from the European Food4Me Study. Molecular Nutrition & Food Research, 61 (10). 1700142. ISSN 1613-4125

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To link to this item DOI: 10.1002/mnfr.201700142

Abstract/Summary

Scope Previous work highlighted the potential of odd-chain length saturated fatty acids as potential markers of dairy intake. The aim of this study was to assess the reproducibility of these biomarkers and their sensitivity to changes in dairy intake. Methods and results Fatty acid profiles and dietary intakes from food frequency questionnaires (FFQs) were measured three times over six months in the Food4Me Study. Reproducibility was explored through intra-class correlation coefficients (ICCs) and within-subject coefficients of variation (WCV). Sensitivity to changes in diet was examined using regression analysis. C15:0 blood levels showed high correlation over time (ICC: 0.62, 95% CI: 0.57, 0.68), however, the ICC for C17:0 was much lower (ICC: 0.32, 95% CI: 0.28, 0.46). The WCV for C15:0 was 16.6% and that for C17:0 was 14.6%. There were significant associations between changes in intakes of total dairy, high-fat dairy, cheese and butter and C15:0; and change in intakes of high-fat dairy and cream and C17:0. Conclusion Results provide evidence of reproducibility of C15:0 levels over time and sensitivity to change in intake of high-fat dairy products with results comparable to the well-established biomarker of fish intake (EPA+DHA).

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Faculty of Life Sciences > School of Agriculture, Policy and Development > Economic and Social Sciences Division > Agricultural and Food Investigational Team (AFIT)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:72125
Publisher:Wiley

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