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Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice

Grimaldi, K. A., van Ommen, B., Ordovas, J. M., Parnell, L. D., Mathers, J. C., Bendik, I., Brennan, L., Celis-Morales, C., Cirillo, E., Daniel, H., de Kok, B., El-Sohemy, A., Fairweather-Tait, S. J., Fallaize, R., Fenech, M., Ferguson, L. R., Gibney, E. R., Gibney, M., Gjelstad, I. M. F., Kaput, J. , Karlsen, A. S., Kolossa, S., Lovegrove, J., Macready, A. L., Marsaux, C. F. M., Martinez, J. A., Milagro, F., Navas-Carretero, S., Roche, H. M., Saris, W. H. M., Traczyk, I., van Kranen, H., Verschuren, L., Virgili, F., Weber, P. and Bouwman, J. (2017) Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice. Genes & Nutrition, 12. 35. ISSN 1865-3499

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To link to this item DOI: 10.1186/s12263-017-0584-0

Abstract/Summary

Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical application of nutrigenetics is the use of personal genetic information to guide recommendations for dietary choices that are more efficacious at the individual or genetic subgroup level relative to generic dietary advice. Nutrigenetics is unregulated, with no defined standards, beyond some commercially adopted codes of practice. Only a few official nutrition-related professional bodies have embraced the subject, and, consequently, there is a lack of educational resources or guidance for implementation of the outcomes of nutrigenetic research. To avoid misuse and to protect the public, personalised nutrigenetic advice and information should be based on clear evidence of validity grounded in a careful and defensible interpretation of outcomes from nutrigenetic research studies. Evidence requirements are clearly stated and assessed within the context of state-of-the-art ‘evidence-based nutrition’. We have developed and present here a draft framework that can be used to assess the strength of the evidence for scientific validity of nutrigenetic knowledge and whether ‘actionable’. In addition, we propose that this framework be used as the basis for developing transparent and scientifically sound advice to the public based on nutrigenetic tests. We feel that although this area is still in its infancy, minimal guidelines are required. Though these guidelines are based on semiquantitative data, they should stimulate debate on their utility. This framework will be revised biennially, as knowledge on the subject increases.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Interdisciplinary centres and themes > Food Chain and Health
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Interdisciplinary centres and themes > Centre for Food Security
Interdisciplinary centres and themes > Institute for Food, Nutrition and Health (IFNH)
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Faculty of Life Sciences > School of Agriculture, Policy and Development > Food Production and Quality Division > Animal, Dairy and Food Chain Sciences (ADFCS)
Faculty of Life Sciences > School of Agriculture, Policy and Development > Economic and Social Sciences Division > Food Economics and Marketing (FEM)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Nutrition and Health
ID Code:74946
Uncontrolled Keywords:Genotype, Dietary advice, Gene-environment interaction, Nutrigenetics, Personalised nutrition, Framework, Genetic variants, Health
Publisher:Springer

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