Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitorsDadashpour, S., Kucukkilinc, T. T., Ayazgok, B., Hosseinimehr, S. J., Chippindale, A., Foroumadi, A. and Irannejad, H. (2019) Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors. Future Medicinal Chemistry, 11 (10). pp. 1119-1136. ISSN 1756-8927
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.4155/fmc-2018-0412 Abstract/SummaryMesenchymal-epithelial transition factor HGF/c-Met overactivation is involved in diverse human cancers. Herein, we report the synthesis and biological evaluation of thiomethylpyridine-linked triazolotriazines as c-Met kinase inhibitors.
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