Yb(III), Sm(III) and La(III) complexes of a tetradentate pyridoxal Schiff base ligand: their DNA-binding activity and bio-imaging applications
Chakraborty, M., Mondal, S., Cardin, C.
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1016/j.poly.2019.114167 Abstract/SummaryYb(III), Sm(III) and La(III) complexes of a tetradentate Schiff base ligand, bis(pyridoxylidene)ethyelenediamine, are reported. Single crystal X-ray crystal structures of the complexes reveal that in all of them the Ln(III) ions are in a distorted dodecahedral geometry with N4O4-coordination environment provided by two coordinated ligands. Fluorescence spectroscopy shows that in the Yb(III) and Sm(III) complexes energy transfer from ligand centered excited state leads to population of emissive f-f excited states. The reported complexes bind to ct-DNA, with high binding constant (Kb) comparable to those which bind by intercalative mode. Cytotoxicity study shows that the complexes have quite low cytotoxicity towards HeLa cell. Further, they exhibited fast response, bright fluorescence and stability at physiological pH, making them suitable for use in fluorescence bio-imaging.
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