Accessibility navigation


Determination of mitochondrial genetic diversity in mammals

Nabholz, B., Mauffrey, J. F., Bazin, E., Galtier, N. and Glemin, S. (2008) Determination of mitochondrial genetic diversity in mammals. Genetics, 178 (1). pp. 351-361. ISSN 0016-6731

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1534/genetics.107.073346

Abstract/Summary

Mitochondrial DNA (mtDNA) is one of the most Popular population genetic markers. Its relevance as an indicator Of Population size and history has recently been questioned by several large-scale studies in animals reporting evidence for recurrent adaptive evolution, at least in invertebrates. Here we focus on mammals, a more restricted taxonomic group for which the issue of mtDNA near neutrality is crucial. By analyzing the distribution of mtDNA diversity across species and relating 4 to allozyme diversity, life-history traits, and taxonomy, we show that (i) mtDNA in mammals (toes not reject the nearly neutral model; (ii) mtDNA diversity, however, is unrelated to any of the 14 life-history and ecological variables that we analyzed, including body mass, geographic range, and The World Conservation Union (IUCN) categorization; (iii) mtDNA diversity is highly variable between mammalian orders and families; (iv) this taxonomic effect is most likely explained by variations of mutation rate between lineages. These results are indicative of a strong stochasticity of effective population size in mammalian species. They Suggest that, even in the absence of selection, mtDNA genetic diversity is essentially unpredictable, knowing species biology, and probably uncorrelated to species abundance.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:9857
Uncontrolled Keywords:POPULATION-SIZE, BODY-SIZE, MOLECULAR EVOLUTION, NUCLEAR GENES, DNA, PHYLOGENIES, POLYMORPHISM, RODENTS, MODEL, VARIABILITY

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation