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Items where Author is "Knight, Professor Phil"

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Mattar, D., Cheewasopit, W., Samir, M. and Knight, P. G. (2023) Does kisspeptin exert a local modulatory effect on bovine ovarian steroidogenesis? Reproduction & Fertility, 4 (1). e220088. ISSN 2633-8386 doi: https://doi.org/10.1530/RAF-22-0088

Mattar, D., Samir, M., Laird, M. and Knight, P. G. (2020) Modulatory effects of TGF-β1 and BMP6 on thecal angiogenesis and steroidogenesis in the bovine ovary. Reproduction, 159 (4). pp. 397-408. ISSN 1470-1626 doi: https://doi.org/10.1530/REP-19-0311

Laird, M., Glister, C., Cheewasopit, W., Satchell, L. S., Bicknell, A. B. and Knight, P. G. (2019) ‘Free’ inhibin α subunit is expressed by bovine ovarian theca cells and its knockdown suppresses androgen production. Scientific Reports, 9. 19793. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-019-55829-w

Glister, C., Regan, S. L., Samir, M. and Knight, P. G. (2019) Gremlin, noggin, chordin and follistatin differentially modulate BMP induced suppression of androgen secretion by bovine ovarian theca cells. Journal of Molecular Endocrinology, 62 (1). pp. 15-25. ISSN 0952-5041 doi: https://doi.org/10.1530/JME-18-0198

Regan, S. L. P., Knight, P. G., Yovich, J. L., Arfuso, F. and Dharmarajan, A. (2018) Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. Fertility and Sterility, 110 (7). pp. 1298-1310. ISSN 0015-0282 doi: https://doi.org/10.1016/j.fertnstert.2018.08.018

Cheewasopit, W., Laird, M., Glister, C. and Knight, P. G. (2018) Myostatin is expressed in bovine ovarian follicles and modulates granulosal and thecal steroidogenesis. Reproduction, 156 (4). pp. 375-386. ISSN 1741-7899 doi: https://doi.org/10.1530/REP-18-0114

Regan, S. L. P., Knight, P. G., Yovich, J. L., Stanger, J. D., Leung, Y., Arfuso, F., Almahbobi, G. and Dharmarajan, A. (2018) The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development. Molecular and Cellular Endocrinology, 470. pp. 219-227. ISSN 0303-7207 doi: https://doi.org/10.1016/j.mce.2017.11.002

Regan, S. L. P., Knight, P. G., Yovich, J. L., Leung, Y., Arfuso, F. and Dharmarajan, A. (2018) Granulosa cell apoptosis in the ovarian follicle - a changing view. Frontiers in Endocrinology, 9. 61. ISSN 1664-2392 doi: https://doi.org/10.3389/fendo.2018.00061

Regan, S. L. P., Knight, P. G., Yovich, J. L., Stanger, J. D., Leung, Y., Arfuso, F., Dharmarajan, A. and Almahbobi, G. (2017) Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles. Molecular and Cellular Endocrinology, 446. pp. 40-51. ISSN 0303-7207 doi: https://doi.org/10.1016/j.mce.2017.02.007

Hatzirodos, N., Glister, C., Hummitzsch, K., Irving-Rodgers, H., Knight, P. G. and Rodgers, R. (2017) Transcriptomal profiling of bovine ovarian granulosa and theca interna cells in primary culture in comparison with their in vivo counterparts. PLoS ONE, 12 (3). e0173391. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0173391

Samir, M. S., Glister, C., Mattar, D., Laird, M. and Knight, P. G. (2017) Follicular expression of pro-inflammatory cytokines tumour necrosis factor-α (TNFα), interleukin 6 (IL6) and their receptors in cattle: TNFα, IL6 and macrophages suppress thecal androgen production in vitro. Reproduction, 154 (1). pp. 35-49. ISSN 1471-7899 doi: https://doi.org/10.1530/REP-17-0053

Regan, S. L. P., Knight, P. G., Yovich, J. L., Stanger, J. D., Leung, Y., Arfuso, F., Dharmarajan, A. and Almahbobi, G. (2016) Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility. Molecular and Cellular Endocrinology, 425. pp. 84-93. ISSN 1872-8057 doi: https://doi.org/10.1016/j.mce.2016.01.016

Glister, C., Sunderland, S. J., Boland, M. P., Ireland, J. J. and Knight, P. G. (2015) Comparison of bioactivities, binding properties and intra-follicular levels of bovine follistatins. Reproduction, 150 (2). pp. 85-96. ISSN 1470-1626 doi: https://doi.org/10.1530/REP-15-0086

Glister, C., Hatzirodos, N., Hummitzsch, K., Knight, P. G. and Rodgers, R. J. (2014) The global effect of follicle-stimulating hormone and tumour necrosis factor α on gene expression in cultured bovine ovarian granulosa cells. BMC Genomics, 15 (1). 72. ISSN 1471-2164 doi: https://doi.org/10.1186/1471-2164-15-72

Anand-Ivell, R., Tremellen, K., Dai, Y., Heng, K., Yoshida, M., Knight, P. G., Hale, G. E. and Ivell, R. (2013) Circulating insulin-like factor 3 (INSL3) in healthy and infertile women. Human reproduction, 28 (11). pp. 3093-3102. ISSN 1460-2350 doi: https://doi.org/10.1093/humrep/det349

Satchell, L., Glister, C., Bleach, E. C., Glencross, R., Bicknell, A., Dai, Y., Anand-Ivell, R., Ivell, R. and Knight, P. G. (2013) Ovarian expression of insulin-like peptide 3 (INSL3) and its receptor (RXFP2) during development of bovine antral follicles and corpora lutea and measurement of circulating INSL3 levels during synchronized estrous cycles. Endocrinology, 154 (5). 1897-1906. ISSN 1945-7170 doi: https://doi.org/10.1210/en.2012-2232

Glister, C., Satchell, L., Bathgate, R. J., Wade, J. D., Dai, Y., Ivell, R., Anand-Ivell, R., Rodgers, R. J. and Knight, P. G. (2013) A functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proceedings of the National Academy of Sciences of the United States of America, 110 (15). E1426-E1435. ISSN 0027-8424 doi: https://doi.org/10.1073/pnas.1222216110

Glister, C., Satchell, L., Michael, A. E., Bicknell, A. B. and Knight, P. G. (2012) The anti-epileptic drug Valproic Acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro. PLoS ONE, 7 (11). e49553. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0049553

Knight, P. G., Satchell, L. and Glister, C. (2012) Intra-ovarian roles of activins and inhibins. Molecular and Cellular Endocrinology, 359 (1-2). pp. 53-65. ISSN 0303-7207 doi: https://doi.org/10.1016/j.mce.2011.04.024

Holtz, W., Wang, X., El-Gayar, M. and Knight, P.G. (2012) The effect of exogenous gonadotropins on ovarian function in goats actively immunized against inhibin. Theriogenology, 77 (12). pp. 253-259. ISSN 0093-691X doi: https://doi.org/10.1016/j.theriogenology.2011.07.037

Glister, C., Satchell, L. and Knight, P. G. (2011) Granulosal and thecal expression of bone morphogenetic protein- and activin-binding protein mRNA transcripts during bovine follicle development and factors modulating their expression in vitro. Reproduction, 142 (4). pp. 581-591. ISSN 1741-7899 doi: https://doi.org/10.1530/REP-11-0150

Glister, C., Satchell, L. and Knight, P. G. (2010) Changes in expression of bone morphogenetic proteins (BMPs), their receptors and inhibin co-receptor betaglycan during bovine antral follicle development: inhibin can antagonize the suppressive effect of BMPs on thecal androgen production. Reproduction, 140 (5). pp. 699-712. ISSN 1470-1626 doi: https://doi.org/10.1530/REP-10-0216

Kayani, A. R., Glister, C. and Knight, P. G. (2009) Evidence for an inhibitory role of bone morphogenetic protein(s) in the follicular-luteal transition in cattle. Reproduction, 137 (1). pp. 67-78. ISSN 1470-1626 doi: https://doi.org/10.1530/rep-08-0198

Ireland, J. J., Zielak-Steciwko, A. E., Jimenez-Krassel, F., Folger, J., Bettegowda, A., Scheetz, D., Walsh, S., Mossa, F., Knight, P. G., Smith, G. W., Lonergan, P. and Evans, A. C. O. (2009) Variation in the ovarian reserve Is linked to alterations in intrafollicular estradiol production and ovarian biomarkers of follicular differentiation and oocyte quality in cattle. Biology of Reproduction, 80 (5). pp. 954-964. ISSN 0006-3363 doi: https://doi.org/10.1095/biolreprod.108.073791

Wang, X. L., El-Gayar, M., Knight, P. G. and Holtz, W. (2009) The long-term effect of active immunization against inhibin in goats. Theriogenology, 71 (2). pp. 318-322. ISSN 0093-691X doi: https://doi.org/10.1016/j.theriogenology.2008.07.024

Veiga-Lopez, A., Ye, W., Phillips, D. J., Herkimer, C., Knight, P. G. and Padmanabhan, V. (2008) Developmental programming: Deficits in reproductive hormone dynamics and ovulatory outcomes in prenatal, testosterone-treated sheep. Biology of Reproduction, 78 (4). pp. 636-647. ISSN 0006-3363 doi: https://doi.org/10.1095/biolreprod.107.065904

Butler, S. T., Pelton, S. H., Knight, P. G. and Butler, W. R. (2008) Follicle-stimulating hormone isoforms and plasma concentrations of estradiol and inhibin A in dairy cows with ovulatory and non-ovulatory follicles during the first postpartum follicle wave. Domestic Animal Endocrinology, 35 (1). pp. 112-119. ISSN 0739-7240 doi: https://doi.org/10.1016/j.domaniend.2008.03.002

Ryan, K. E., Glister, C., Lonergan, P., Martin, F., Knight, P. G. and Evans, A. C. (2008) Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep. Journal of Ovarian Research, 1 (1). p. 2. ISSN 1757-2215 doi: https://doi.org/10.1186/1757-2215-1-2

Padilla, G., Knight, P. G. and Holtz, W. (2008) Superovulation and embryo collection in nulliparous Boer goat does immunized against a recombinant ovine alpha-subunit inhibin. Small Ruminant Research, 74 (1-3). pp. 159-164. ISSN 0921-4488 doi: https://doi.org/10.1016/j.smallrumres.2007.05.006

Al-Musawi, S. L., Gladwell, R. T. and Knight, P. G. (2007) Bone morphogenetic protein-6 enhances gonadotrophin-dependent progesterone and inhibin secretion and expression of rnRNA transcripts encoding gonadotrophin receptors and inhibin/activin subunits in chicken granulosa cells. Reproduction, 134 (2). pp. 293-306. ISSN 1470-1626 doi: https://doi.org/10.1530/rep-07-0070

Lovell, T. M., Al-Musawi, S. L., Gladwell, R. T. and Knight, P. G. (2007) Gonadotrophins modulate hormone secretion and steady-state mRNA levels for activin receptors (type I, IIA, IIB) and inhibin co-receptor (betaglycan) in granulosa and theca cells from chicken prehierarchical and preovulatory follicles. Reproduction, 133 (6). pp. 1159-1168. ISSN 1470-1626 doi: https://doi.org/10.1530/rep-06-0179

Glister, C., Groome, N. P. and Knight, P. G. (2006) Bovine follicle development is associated with divergent changes in activin-A, inhibin-A and follistatin and the relative abundance of different follistatin isoforms in follicular fluid. Journal of Endocrinology, 188 (2). pp. 215-225. ISSN 0022-0795 doi: https://doi.org/10.1677/joe.1.06485

Lovell, T. M., Knight, P. G. and Gladwell, R. (2006) Differential expression of mRNAs encoding co-receptor (betaglycan) and activin type-I preovulatory and prehierarchical follicles of the putative inhibin and type-II receptors in the laying hen ovary. Journal of Endocrinology, 188 (2). pp. 241-249. ISSN 0022-0795 doi: https://doi.org/10.1677/joe.1.06525

Silva, C. C., Rosa, H. J. D. and Knight, P. G. (2006) Seasonal variations in the developmental competence of bovine oocytes matured in vitro. Veterinary Record, 158 (14). pp. 473-475. ISSN 0042-4900

Knight, P. G. and Glister, C. (2006) TGF-beta superfamily members and ovarian follicle development. Reproduction, 132 (2). pp. 191-206. ISSN 1470-1626 doi: https://doi.org/10.1530/rep.1.01074

Glister, C., Richards, S. L. and Knight, P. G. (2005) Bone morphogenetic proteins (BMP)-4,-6, and-7 potently suppress basal and luteinizing hormone-induced androgen production by bovine theca interna cells in primary culture: Could ovarian hyperandrogenic dysfunction be caused by a defect in thecal BMP signaling? Endocrinology, 146 (4). pp. 1883-1892. ISSN 0013-7227 doi: https://doi.org/10.1210/en.2004-1303

Burns, D. S., Jimenez-Krassel, F., Ireland, J. L. H., Knight, P. G. and Ireland, J. J. (2005) Numbers of antral follicles during follicular waves in cattle: Evidence for high variation among animals, very high repeatability in individuals, and an inverse association with serum follicle-stimulating hormone concentrations. Biology of Reproduction, 73 (1). pp. 54-62. ISSN 0006-3363 doi: https://doi.org/10.1095/biolreprod.104.036277

Lovell, T. M., Knight, P. G. and Gladwell, R. T. (2005) Variation in pituitary expression of mRNAs encoding the putative inhibin co-receptor (betaglycan) and type-I and type-II activin receptors during the chicken ovulatory cycle. Journal of Endocrinology, 186 (3). pp. 447-455. ISSN 0022-0795 doi: https://doi.org/10.1677/joe.1.06303

Bleach, E. C. L., Glencross, R. G. and Knight, P. G. (2004) Association between ovarian follicle development and pregnancy rates in dairy cows undergoing spontaneous oestrous cycles. Reproduction, 127 (5). pp. 621-629. ISSN 1470-1626 doi: https://doi.org/10.1530/rep.1.00190

Glister, C., Kemp, C. F. and Knight, P. G. (2004) Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4,-6 and-7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin. Reproduction, 127 (2). pp. 239-254. ISSN 1470-1626 doi: https://doi.org/10.1530/rep.1.00090

Hirst, R. C., Abel, M. H., Wilkins, V., Simpson, C., Knight, P. G., Zhang, F. P., Huhtaniemi, I., Kumar, T. R. and Charlton, H. M. (2004) Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary. Reproduction, 128 (1). pp. 43-52. ISSN 1470-1626 doi: https://doi.org/10.1530/rep.1.00176

Ryan, K. E., Glister, C., Martin, F., Knight, P. G. and Evans, A. C. O. (2003) Effect of FSH and IGF on Akt and Erk pathways, estradiol, and inhibin-A secretion, and survival/proliferation of bovine granulosa cells in vitro. Biology of Reproduction, 68. p. 423. ISSN 0006-3363

Silva, C. C., Groome, N. P. and Knight, P. G. (2003) Immunohistochemical localization of inhibin/activin alpha, beta(A) and beta(B) subunits and follistatin in bovine oocytes during in vitro maturation and fertilization. Reproduction, 125 (1). pp. 33-42. ISSN 1470-1626 doi: https://doi.org/10.1530/rep.0.1250033

Knight, P. G. and Glister, C. (2003) Local roles of TGF-beta superfamily members in the control of ovarian follicle development. Animal Reproduction Science, 78 (3-4). pp. 165-183. ISSN 0378-4320 doi: https://doi.org/10.1016/s0378-4320(03)00089-7

Glister, C., Groome, N. P. and Knight, P. G. (2003) Oocyte-mediated suppression of follicle-stimulating hormone- and insulin-like growth factor-induced secretion of steroids and inhibin-related proteins by bovine granulosa cells in vitro: Possible role of transforming growth factor alpha. Biology of Reproduction, 68 (3). pp. 758-765. ISSN 0006-3363 doi: https://doi.org/10.1095/biolreprod.102.008698

Lovell, T. M., Gladwell, R. T., Groome, N. P. and Knight, P. G. (2003) Ovarian follicle development in the laying hen is accompanied by divergent changes in inhibin A, inhibin B, activin A and follistatin production in granulosa and theca layers. Journal of Endocrinology, 177 (1). pp. 45-55. ISSN 0022-0795

Anderson, G. M., Lapwood, K. R., Knight, P. G. and Parkinson, T. J. (2003) The reproductive response of rams to thyroidectomy: mediation by impaired inhibin feedback rather than a change in LH pulsatility. Reproduction, 126 (3). pp. 353-364. ISSN 1470-1626 doi: https://doi.org/10.1530/rep.0.1260353

Book or Report Section

Regan, S. L. P., Knight, P. G., Yovich, J. L., Leung, Y., Arfuso, F. and Dharmarajan, A. (2018) Involvement of Bone Morphogenetic Proteins (BMP) in the regulation of ovarian function. In: Litwack, G. (ed.) Ovarian Cycle. Vitamins and Hormones (107). Elsevier, pp. 227-261. ISBN 9780128143599 doi: https://doi.org/10.1016/bs.vh.2018.01.015

Knight, P. and Glister, C. (2014) Theca cells and the regulation of ovarian androgen production. In: Juengel, J. L., Miyamoto, A., Price, C., Reynolds, L. P., Smith, M. F. and Webb, R. (eds.) Reproduction in Domestic Ruminants. Bioscientifica Proceedings, VIII. Context, Ashby de la Zouche, pp. 295-310. ISBN 9781899043637 doi: https://doi.org/10.1530/biosciprocs.8.021

Knight, P.G., Al-Musawi, S.L., Lovell, T.M. and Gladwell, R.T. (2009) Control of follicular development: intra-ovarian actions of transforming growth factor-beta (TGF-b) superfamily members. In: Hocking, P.M. (ed.) Biology of Breeding Poultry. CAB International, Wallingford, pp. 89-107. ISBN 9781845933753

Knight, P.G., Gladwell, R.T. and Lovell, T.M. (2005) The inhibin-activin system and ovarian folliculogenesis in the chicken. In: Dawson, A. and Sharp, P.J. (eds.) Functional Avian Endocrinology. Alpha Science International Ltd, New Delhi, India, pp. 323-340. ISBN 9788173195686

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