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Alemi, F., Kwon, E., Poole, D. P., Lieu, T., Lyo, V., Cattaruzza, F., Cevikbas, F., Steinhoff, M., Nassini, R., Materazzi, S., Guerrero-Alba, R., Valdez-Morales, E., Cottrell, G., Schoonjans, K., Geppetti, P., Vanner, S. J., Bunnett, N. W. and Corvera, C. U. (2013) The TGR5 receptor mediates bile acid-induced itch and analgesia. The Journal of Clinical Investigation, 123 (4). pp. 1513-1530. ISSN 0021-9738 doi: 10.1172/JCI64551

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Amadesi, S., Grant, A. D., Cottrell, G., Vaksmam, N., Poole, D. P., Rozengurt, E. and Bunnett, N. W. (2009) Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2. Journal of Comparative Neurology, 516 (2). pp. 141-156. ISSN 1096-9861 doi: 10.1002/cne.22104

Amadesi, S., Nie, J., Vergnolle, N., Cottrell, G. S., Grady, E. F., Trevisani, M., Manni, C., Geppetti, P., McRoberts, J. A., Ennes, H., Davis, J. B., Mayer, E. A. and Bunnett, N. W. (2004) Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. The Journal of Neuroscience, 24 (18). pp. 4300-4312. ISSN 1529-2401 doi: 10.1523/JNEUROSCI.5679-03.2004

Anderson, D. B., Cimarosti, H. I. and Henley, J. M. (2009) The role of sumoylation in neurodegenerative diseases. In: Wilson, V. G. (ed.) SUMO regulation of cellular processes. Springer, pp. 233-251. ISBN 9789048126484 doi: 10.1007/978-90-481-2649-1_14

Aravindan, L. , Bicknell, K. A., Brooks, G., Khutoryanskiy, V. V. and Williams, A. C. (2009) Effect of acyl chain length on transfection efficiency and toxicity of polyethylenimine. International Journal of Pharmaceutics, 378 (1-2). pp. 201-210. ISSN 0378-5173 doi: 10.1016/j.ijpharm.2009.05.052

Bahia, P. K., Pugh, V., Hoyland, K., Hensley, V., Rattray, M. and Williams, R. J. (2012) Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. Journal of Neurochemistry, 123 (1). pp. 182-191. ISSN 0022-3042 doi: 10.1111/j.1471-4159.2012.07877.x

Bahia, P.K., Rattray, M. and Williams, R.J. (2008) Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes. Journal of Neurochemistry, 106 (5). pp. 2194-2204. ISSN 0022-3042 doi: 10.1111/j.1471-4159.2008.05542.x

Baillie, G. L. , Horswill, J., Anavi-Goffer,, S. , Reggio, P. H. , Bolognini , D. , Abood, M. E. , McAllister, S. , Strange, P., Stephens, G., Pertwee, R. G. and Ross, R. A. (2013) CB1 receptor allosteric modulators display both agonist and signaling pathway specificity. Molecular Pharmacology, 82 (2). pp. 322-338. ISSN 1521-0111 doi: 10.1124/mol.112.080879

Baksh, M. F. and Kelly, P. (2008) Statistical methods for examining genetic influences of resistance to anti-epileptic drugs. Expert Review of Clinical Pharmacology, 1 (1). pp. 137-144. ISSN 1751-2433 doi: 10.1586/17512433.1.1.137

Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., Collins, S. M. and Corinaldesi, R. (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology, 126 (3). pp. 693-702. ISSN 0016-5085 doi: 10.1053/j.gastro.2003.11.055

Bicknell, K. A., Harmer, S. C., Yiangson, S., Lockwood, W. and Bicknell, A. B. (2009) Lys-gamma3-MSH: a global regulator of hormone sensitive lipase activity? Molecular and Cellular Endocrinology , 300 (1-2). pp. 71-76. ISSN 0303-7207 doi: 10.1016/j.mce.2008.09.032

Boateng, S. Y., Senyo, S. E., Qi, L. X., Goldspink, P. H. and Russell, B. (2009) Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein. Journal of Molecular and Cellular Cardiology, 47 (4). pp. 426-435. ISSN 0022-2828 doi: 10.1016/j.yjmcc.2009.04.006

Brazier, J. A., Fisher, J. and Cosstick, R. (2005) Stabilization of the DNA I-motif structure by incorporation of 3 '-S-phosphorothiolate linkages. Angewandte Chemie-International Edition, 45 (1). pp. 114-117. ISSN 1521-3773 doi: 10.1002/anie.200503110

Bucci, G., Mochida, S. and Stephens, G. J. (2011) Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2+ channel peptides. Journal of Physiology, 589 (13). pp. 3085-3101. ISSN 0022-3751 doi: 10.1113/jphysiol.2010.204735

Carbone, M., Duty, S. and Rattray, M. (2012) Riluzole elevates GLT-1 activity and levels in striatal astrocytes. Neurochemistry International, 60 (1). pp. 31-38. ISSN 0197-0186 doi: 10.1016/j.neuint.2011.10.017

Carbone, M., Duty, S. and Rattray, M. (2012) Riluzole neuroprotection in a parkinson’s disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. BMC Neuroscience, 13. 38. ISSN 1471-2202 doi: 10.1186/1471-2202-13-38 (In Press)

Castelletto, V., Hamley, I. W., Stain, C. and Connon, C. (2012) Slow-release RGD-peptide hydrogel monoliths. Langmuir, 28 (34). pp. 12575-12580. ISSN 0743-7463 doi: 10.1021/la302071e

Cave, R., Cook, J., Connon, C. J. and Khutoryanskiy, V. V. (2012) A flow system for the on-line quantitative measurement of the retention of dosage forms on biological surfaces using spectroscopy and image analysis. International Journal of Pharmaceutics, 428 (1-2). pp. 96-102. ISSN 0378-5173 doi: 10.1016/j.ijpharm.2012.02.047

Cenac, N. ., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G. S., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., Sharkey, K. A., Ferraz, J. G., Shaffer, E. and Vergnolle, N. (2007) Role for protease activity in visceral pain in irritable bowel syndrome. The Journal of Clinical Investigation, 117 (3). pp. 636-647. ISSN 0021-9738 doi: 10.1172/JCI29255

Chen, B., Jones, R. R., Mi, S., Foster, J., Alcock, S., Hamley, I. and Connon, C. (2012) The mechanical properties of amniotic membrane influence its effect as a biomaterial for ocular surface repair. Soft Matter, 8 (32). pp. 8379-8387. ISSN 1744-683X doi: 10.1039/C2SM26175H

Chen, B., Mi, S., Wright, B. and Connon, C. J. (2010) Investigation of K14/K5 as a stem cell marker in the limbal region of the bovine cornea. PLoS ONE, 5 (10). e13192. ISSN 1932-6203 doi: 10.1371/journal.pone.0013192

Chen, B., Wright, B., Sahoo, R. and Connon, C. J. (2013) A novel alternative to cryopreservation for the short-term storage of stem cells for use in cell therapy using alginate encapsulation. Tissue Engineering Part C : methods. ISSN 1937-3384 doi: 10.1089/ten.tec.2012.0489

Chen, B., Mi, S., Wright, B. and Connon, C. J. (2010) Differentiation status of limbal epithelial cells cultured on intact and denuded amniotic membrane before and after air-lifting. Tissue Engineering, 16 (9). pp. 2721-2729. ISSN 1937-3341

Cheng, G., Castelletto, V., Jones, R. R., Connon, C. J. and Hamley, I. W. (2011) Hydrogelation of self-assembling RGD-based peptides. Soft Matter, 7 (4). pp. 1326-1333. ISSN 1744-683X doi: 10.1039/C0SM00408A

Cimarosti, H. and Henley, J. M. (2008) Investigating the mechanisms underlying neuronal death in ischemia using in vitro oxygen-glucose deprivation: potential involvement of protein SUMOylation. The Neuroscientist, 14 (6 ). pp. 626-636. ISSN 1089-4098 doi: 10.1177/1073858408322677

Cimarosti, H., Ashikaga, E., Jaafari, N., Dearden , L., Rubin, P., Wilkinson, K. A. and Henley, J. M. (2012) Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones. Journal of Cerebral Blood Flow and Metabolism, 32 (1). pp. 17-22. ISSN 1559-7016 doi: 10.1038/jcbfm.2011.146

Cimarosti, H., Kantamneni, S. and Henley, J. M. (2009) Ischaemia differentially regulates GABAB receptor subunits in organotypic hippocampal slice cultures. Neuropharmacology, 56 (8). pp. 1088-1096. ISSN 0028-3908 doi: 10.1016/j.neuropharm.2009.03.007

Cimarosti, H., Lindberg, C. , Bomholt, S. F. , Rønn, L. C.B. and Henley, J. M. (2008) Increased protein SUMOylation following focal cerebral ischemia. Neuropharmacology, 54 (2). pp. 280-289. ISSN 0028-3908 doi: 10.1016/j.neuropharm.2007.09.010

Connon, C. J., Doutch, J., Chen, B., Hopkinson, A., Mehta, J., Nakamura, T., Kinoshita, S. and Meek, K. (2010) The variation in transparency of amniotic membrane used in ocular surface regeneration. British Journal of Ophthalmology, 94 (8). pp. 1057-1061. ISSN 0007-1161 doi: 10.1136/bjo.2008.153064

Connon, C. J., Nakamura, T., Hopkinson, A., Quantock, A., Yagi, N., Doutch, J. and Meek, K. M. (2007) The biomechanics of amnion rupture: an X-ray diffraction study. PLoS ONE, 2 (11). e1147. ISSN 1932-6203 doi: 10.1371/journal.pone.0001147

Cottrell, G. S. (2013) Roles of proteolysis in regulation of G protein-coupled receptor function. British Journal of Pharmacology, 168 (3). pp. 576-590. ISSN 1476-5381 doi: 10.1111/j.1476-5381.2012.02234.x

Cottrell, G. S., Amadesi, S., Grady, E. F. and Bunnett, N. W. (2004) Trypsin IV, a novel agonist of protease-activated receptors 2 and 4. Journal of Biological Chemistry, 279 (14). pp. 13532-13539. ISSN 1083-351X doi: 10.1074/jbc.M312090200

Cottrell, G. S., Amadesi, S., Pikios, S., Camerer, E., Willardsen, J. A., Murphy, B. R., Caughey, G. H., Wolters, P. J., Coughlin, S. R., Peterson, A., Knecht, W., Pothoulakis, C., Bunnett, N. W. and Grady, E. F. (2007) Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology, 132 (7). pp. 2422-2437. ISSN 0016-5085 doi: 10.1053/j.gastro.2007.03.101

Cottrell, G. S., Amadesi, S., Schmidlin, F. and Bunnett, N. (2003) Protease-activated receptor 2: activation, signalling and function. Biochemical Society Transactions, 31 (6). pp. 1191-1197. ISSN 1470-8752

Cottrell, G. S., Coelho, A. M. and Bunnett, N. W. (2002) Protease-activated receptors: the role of cell-surface proteolysis in signalling. Essays in Biochemistry, 38. pp. 169-183. ISSN 0071-1365

Cottrell, G. S., Hooper, N. M. and Turner, A. J. (2000) Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme. Biochemistry, 39 (49). pp. 15121-15128. ISSN 0006-2960 doi: 10.1021/bi001585c

Cottrell, G. S., Hyde, R. J., Hooper, N. M. and Turner, A. J. (1998) The cloning and functional expression of human pancreatic aminopeptidase P. Biochemical Society Transactions, 26 (3). S248. ISSN 1470-8752

Cottrell, G. S., Hyde, R. J., Lim, J., Parsons, M. R., Hooper, N. M. and Turner, A. J. (2000) Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P. Biochemistry, 39 (49). pp. 15129-15135. ISSN 0006-2960 doi: 10.1021/bi0015865

Cottrell, G. S., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Gehringer, D., Grady, E. F. and Bunnett, N. W. (2006) Ubiquitin-dependent down-regulation of the neurokinin-1 receptor. The Journal of Biological Chemistry, 281 (38). pp. 27773-27783. ISSN 1083-351X doi: 10.1074/jbc.M603369200

Cottrell, G. S., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Grady, E. F. and Bunnett, N. W. (2007) Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. The Journal of Biological Chemistry, 282 (16). pp. 12260-12271. ISSN 1083-351X doi: 10.1074/jbc.M606338200

Cottrell, G. S., Roosterman, D., Marvizon, J.-C., Song, B., Wick, E., Pikios, S., Wong, H., Berthelier, C., Tang, Y., Sternini, C., Bunnett, N. W. and Grady, E. F. (2005) Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat. Journal of Comparative Neurology, 490 (3). pp. 239-255. ISSN 1096-9861 doi: 10.1002/cne.20669

Coxon, C. H., Bicknell, K. A., Moseley, F. L. and Brooks, G. (2009) Over expression of Plk1 does not induce cell division in rat cardiac myocytes in vitro. PLoS ONE, 4 (8). e6752. ISSN 1932-6203 doi: 10.1371/journal.pone.0006752

De Silva, D. J., French, S. J., Cheung, N. Y., Swinson, A. K., Bendotti, C. and Rattray, M. (2005) Rat brain serotonin neurones that express neuronal nitric oxide synthase have increased sensitivity to the substituted amphetamine serotonin toxins 3,4-methylenedioxymethamphetamine and p-chloroamphetamine. Neuroscience, 134 (4). pp. 1363-75. ISSN 0306-4522 doi: 10.1016/j.neuroscience.2005.05.016

Deng, J., Lewis, P. A., Greggio, E., Sluch, E., Beilina, A. and Cookson, M. A. (2008) Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proceedings of the National Academy of Sciences, 105 (5). pp. 1499-1504. ISSN 1091-6490 doi: 10.1073/pnas.0709098105

Dennis, I., Whalley, B. J. and Stephens, G. J. (2008) Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes. British Journal of Pharmacology, 154 (6). pp. 1349-58. ISSN 0007-1188 doi: 10.1038/bjp.2008.190

Dennis, S., Jaafari, N., Cimarosti, H., Hanley, J. G., Henley, J. M. and Mellor, J. R. (2011) Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors. The Journal of Neuroscience, 31 (33). pp. 11941-11952. ISSN 1529-2401 doi: 10.1523/JNEUROSCI.1183-11.2011

Devine, M. J., Kaganovich, A., Ryten, M., Mamais, A., Trabzuni, D., Manzoni, C., McGoldrick, P., Chan, D., Dillman, A., Zerle, J., Horan, S., Taanman, J.-W., Hardy, J., Marti-Masso, J.-F., Healy, D., Schapira, A. H., Wolozin, B., Bandopadhyay, R., Cookson, M. R., van der Brug, M. P. and Lewis, P. A. (2011) Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue. PLoS ONE, 6 (7). e22489. ISSN 1932-6203 doi: 10.1371/journal.pone.0022489

Dolman, D., Drndarski, S., Abbott, N. J. and Rattray, M. (2005) Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture. Journal of Neurochemistry, 93 (4). pp. 825-33. ISSN 1471-4159 doi: 10.1111/j.1471-4159.2005.03111.x

Dora, K. A., Gallagher, N. T., McNeish, A. and Garland, C. J. (2008) Modulation of endothelial cell KCa3.1 Channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries. Circulation Research, 102 (10). pp. 1427-1255. ISSN 0009-7330 doi: 10.1161/CIRCRESAHA.108.172379

Dulon, S., Leduc, D., Cottrell, G. S., D'Alayer, J., Hansen, K. K., Bunnett, N. W., Hollenberg, M. D., Pidard, D. and Chignard, M. (2005) Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 32 (5). pp. 411-419. ISSN 1044-1549 doi: 10.1165/rcmb.2004-0274OC

Farrimond, J. A., Mercier, M. S., Whalley, B. J. and Williams, C. M. (2011) Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation. Phytotherapy Research, 25 (2). pp. 170-188. ISSN 0951-418X

Farrimond, J. A., Whalley, B. J. and Williams, C. M. (2012) Cannabinol and cannabidiol exert opposing effects on rat feeding patterns. Psychopharmacology, 223 (1). pp. 117-129. ISSN 0033-3158 doi: 10.1007/s00213-012-2697-x

Farrimond, J. A., Whalley, B. and Williams, C. (2012) Non-D9-tetrahydrocannabinol phytocannabinoids stimulate feeding in rats. Behavioural Pharmacology, 23 (1). pp. 113-117. ISSN 0955-8810 doi: 10.1097/FBP.0b013e32834ed832

Farrimond, J., Hill, A. J., Jones, N., Stephens, G. J., Whalley, B. J. and Williams, C. M. (2009) A cost-effective high-throughput digital system for observation and acquisition of animal behavioral data. Behavior Research Methods, 41 (2). pp. 446-451. ISSN 1554-351X doi: 10.3758/BRM.41.2.446

Farrimond, J., Whalley, B. J. and Williams, C. M. (2010) A low delta-9-tetrahydrocannabinol cannabis extract induces hyperphagia in rats. Behavioural Pharmacology, 21 (8). pp. 769-772. ISSN 0955-8810 doi: 10.1097/FBP.0b013e328340a062

Farrimond, J., Whalley, B. J. and Williams, C. M. (2010) Cannabis constituents modulate ∆9-tetrahydrocannabinol-induced hyperphagia in rats. Psychopharmacology, 210 (1). pp. 97-106. ISSN 0033-3158 doi: 10.1007/s00213-010-1821-z

Feng, Y., Foster, J., Mi, S., Chen, B. and Connon, C. (2012) Influence of substrate on corneal epithelial cell viability within ocular surface models. Experimental Eye Research, 101. pp. 97-103. ISSN 0014-4835 doi: 10.1016/j.exer.2012.05.005

File, S. E., Hartley, D. E., Alom, N. and Rattray, M. (2003) Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats. Neuroscience Letters, 338 (2). pp. 135-138. ISSN 0304-3940 doi: 10.1016/S0304-3940(02)01391-5

Gazzieri, D., Trevisani, M., Springer, J., Harrison, S., Cottrell, G. S., Andre, E., Nicoletti, P., Massi, D., Zecchi, S., Nosi, D., Santucci, M., Gerard, N. P., Lucattelli, M., Lungarella, G., Fischer, A., Grady, E. F., Bunnett, N. W. and Geppetti, P. (2007) Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury. Free Radical Biology and Medicine, 43 (4). pp. 581-589. ISSN 0891-5849 doi: 10.1016/j.freeradbiomed.2007.05.018

Grant, A. D., Cottrell, G. S., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cenac, N., Zamponi, G. W., Bautista-Cruz, F., Lopez, C. B., Joseph, E. K., Levine, J. D., Liedtke, W., Vanner, S., Vergnolle, N., Geppetti, P. and Bunnett, N. W. (2007) Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. Journal of Physiology, 578 (3). pp. 715-733. ISSN 0022-3751 doi: 10.1113/jphysiol.2006.121111

Hasdemir, B., Bunnett, N. W. and Cottrell, G. S. (2007) Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor. The Journal of Biological Chemistry, 282 (40). pp. 29646-57. ISSN 1083-351X doi: 10.1074/jbc.M702974200

Hayat, S., Williams, R.J. and Rattray, M. (2006) Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro. Journal of Psychopharmacology, 20 (2). pp. 257-263. ISSN 1461-7285 doi: 10.1177/0269881106063273

Hill, A. J., Mercier, M. S., Hill, T. D., Glyn, S. E., Jones, N. A., Yamasaki, Y., Futamura, T., Duncan, M., Stott, C.G., Stephens, G.J., Williams, C. M. and Whalley, B.J. (2012) Cannabidivarin is anticonvulsant in mouse and rat in vitro and in seizure models. British Journal of Pharmacology, 167 (8). pp. 1629-1642. ISSN 0007-1188 doi: 10.1111/j.1476-5381.2012.02207.x

Hill, A. J., Williams, C. M., Whalley, B. J. and Stephens, G. J. (2012) Phytocannabinoids as novel therapeutic agents in CNS disorders. Pharmacology & Therapeutics, 133 (1). pp. 79-97. ISSN 0163-7258 doi: 10.1016/j.pharmthera.2011.09.002

Hill, A. J., Jones, N., Williams, C. M., Stephens, G. J. and Whalley, B. J. (2010) Development of multi-electrode array screening for anticonvulsants in acute rat brain slices. Journal of Neuroscience Methods, 185 (2). 246 -256 . ISSN 0165-0270 doi: 10.1016/j.jneumeth.2009.10.007

Hill, A. J., Weston, S. E., Jones, N., Smith, I., Bevan , S., Williamson, E. M., Stephens, G. J., Williams, C. M. and Whalley, B. J. (2010) Δ9-tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rat. Epilepsia, 51 (8). pp. 1522-1532. ISSN 0013-9580 doi: 10.1111/j.1528-1167.2010.02523.x

Hooper, C. L., Dash, P. R. and Boateng, S. Y. (2012) Lipoma preferred partner is a mechanosensitive protein regulated by nitric oxide in the heart. FEBS Open Bio, 2. pp. 135-144. ISSN 2211-5463 doi: 10.1016/j.fob.2012.05.005 (In Press)

Ikematsu , N., Dallas, M. L., Ross, F. A., Lewis , R. W., Rafferty , J. N., David , J. A., Surman, R., Peers, C., Hardie, D. G. and Evans, A. M. (2011) Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability. Proceedings of the National Academy of Sciences of the United States of America, 108 (44). pp. 18132-18137. ISSN 0027-8424 doi: 10.1073/pnas.1106201108

Jacob, C., Cottrell, G. S., Gehringer, D., Schmidlin, F., Grady, E. F. and Bunnett, N. W. (2005) c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. The Journal of Biological Chemistry, 280 (16). pp. 76-87. ISSN 1083-351X doi: 10.1074/jbc.M500109200

Jacob, C., Yang, P.-C., Darmoul, D., Amadesi, S., Saito, T., Cottrell, G. S., Coelho, A.-M., Singh, P., Grady, E. F., Perdue, M. and Bunnett, N. W. (2005) Mast cell tryptase controls paracellular permeability of the intestine: role of protease-activated receptor 2 and beta-arrestins. Journal of Biological Chemistry, 280 (31). pp. 936-948. ISSN 1083-351X doi: 10.1074/jbc.M506338200

Jebelli, J. D., Dihanich, S., Civiero, L., Manzoni, C., Greggio, E. and Lewis, P. A. (2012) GTP binding and intramolecular regulation by the ROC domain of Death Associated Protein Kinase 1. Scientific Reports, 2. 695. ISSN 2045-2322 doi: 10.1038/srep00695

Jones, N. A., Glyn, S., Akiyama, S., Hill, T. D.M., Hill, A., Weston, S., Burnett, M. D.A., Yamasaki, Y., Stephens, G., Whalley, B. and Williams, C. (2012) Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure, 21 (5). pp. 344-352. ISSN 1059-1311 doi: 10.1016/j.seizure.2012.03.001

Jones, N. A., Hill, A. J., Smith, I., Bevan, S. A., Williams, C. M., Whalley, B. J. and Stephens, G. J. (2010) Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics, 332 (2). pp. 569-577. ISSN 0022-3565 doi: 10.1124/jpet.109.159145

Jones, R. R., Hamley, I. and Connon, C. (2012) Ex vivo expansion of limbal stem cells is affected by substrate properties. Stem Cell Research, 8 (3). pp. 403-409. ISSN 1876-7753 doi: 10.1016/j.scr.2012.01.001

Khan, A., Benboubetra, M., Sayyed, P. Z., Ng, K. W., Fox, S., Beck, G., Benter, I. F. and Akhtar, S. (2004) Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies. Journal of Drug Targeting, 12 (6). pp. 393-404. ISSN 1061-186X doi: 10.1080/10611860400003858

Kirkland, J. G., Cottrell, G. S., Bunnett, N. W. and Corvera, C. U. (2007) Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder. American Journal of Physiology Gastrointestinal and Liver Physiology, 293 (1). G335-G346. ISSN 0193-1857 doi: 10.1152/ajpgi.00425.2006

Knecht, W., Cottrell, G. S., Amadesi, S., Mohlin, J., Skaregarde, A., Gedda, K., Peterson, A., Chapman, K., Hollenberg, M. D., Vergnolle, N. and Bunnett, N. W. (2007) Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia. The Journal of Biological Chemistry, 282 (36). pp. 26089-26100. ISSN 1083-351X doi: 10.1074/jbc.M703840200

Leoni, G., Rattray, M. and Butt, A. M. (2009) NG2 cells differentiate into astrocytes in cerebellar slices. Molecular and Cellular Neuroscience, 42 (3). pp. 208-218. ISSN 1044-7431 doi: 10.1016/j.mcn.2009.07.007

Lewis, P. A. and Cookson, M. R. (2012) Gene expression in the Parkinson's disease brain. Brain Research Bulletin, 88 (4). pp. 302-312. ISSN 0361-9230 doi: 10.1016/j.brainresbull.2011.11.016

Long, P., Mercer, A., Begum, R., Stephens, G. J., Sihra, T. and Jovanovic, J. (2009) Nerve terminal GABAA receptors activate Ca2+/calmodulin-dependent signaling to inhibit voltage-gated Ca2+ influx and glutamate release. The Journal of Biological Chemistry, 284 (13). pp. 8717-8728. ISSN 1083-351X doi: 10.1074/jbc.M805322200

Ma, Y. L., Weston, S. E., Whalley, B. J. and Stephens, G. J. (2008) The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum. British Journal of Pharmacology, 154 (1). pp. 204-215. ISSN 0007-1188 doi: 10.1038/bjp.2008.57

Malas, S., Postlethwaite, M., Ekonomou, A., Whalley, B., Nishiguchi, S., Wood, H., Meldrum, B., Constanti, A. and Episkopou, V. (2003) Sox1-deficient mice suffer from epilepsy associated with abnormal ventral forebrain development and olfactory cortex hyperexcitability. Neuroscience, 119 (2). pp. 421-432. ISSN 0306-4522 doi: 10.1016/S0306-4522(03)00158-1

Marshall, A.J., Rattray, M. and Vaughan, P.F. (2006) Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative alpha-secretases, ADAM10 and TACE, without altering their mRNA levels. Brain Research, 1099 (1). pp. 18-24. ISSN 0006-8993 doi: 10.1016/j.brainres.2006.05.008

McMillan , L. E., Brown, J. T., Henley, J. M. and Cimarosti, H. (2011) Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model. Neuroscience Letters, 502 (3). pp. 201-208. ISSN 0304-3940 doi: 10.1016/j.neulet.2011.07.045

McNeish, A., Altayo-Jimenez, F., Cottrell, G. and Garland, C. (2012) Statins and selective inhibition of Rho kinase protect small conductance calcium-activated potassium channel function (KCa2.3) in cerebral arteries. PLoS ONE, 7 (10). e46735. ISSN 1932-6203 doi: 10.1371/journal.pone.0046735

McNeish, A., Altayo-Jimenez, F. and Garland, C. J. (2010) Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat. Vascular Pharmacology, 53 (3-4). pp. 151-159. ISSN 1537-1891 doi: 10.1016/j.vph.2010.06.002

McNeish, A. and Garland , C. J. (2007) Thromboxane A2 inhibition of SKCa after NO synthase block in rat middle cerebral artery. British Journal of Pharmacology, 151 (4). pp. 441-449. ISSN 1476-5381 doi: 10.1038/sj.bjp.0707240

McNeish, A., Roux, B. T., Aylett, S.-B. , Massen Van Den Brink, A. and Cottrell, G. S. (2012) Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries. British Journal of Pharmacology, 167 (8). pp. 1679-1690. ISSN 1476-5381 doi: 10.1111/j.1476-5381.2012.02129.x

McNeish, A., Sandow, S.L., Neylon, C.B., Chen, M.X., Dora, K. A. and Garland, C.J. (2006) Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. Stroke, 37 (5). pp. 1277-1282. ISSN 0039-2499 doi: 10.1161/01.STR.0000217307.71231.43

McNeish, A. J., Dora, K. A. and Garland, C. J. (2005) Possible role for K+ in endothelium-derived hyperpolarizing factor–linked dilatation in rat middle cerebral artery. Stroke, 36 (7). pp. 1526-1532. ISSN 0039-2499 doi: 10.1161/01.STR.0000169929.66497.73

McNeish, A. J., Jimenez-Altayo, F., Cottrell, G. S. and Garland, C. J. (2012) Statins and selective inhibition of rho kinase protect small conductance calcium-activated potassium channel function (k(ca)2.3) in cerebral arteries. PLoS ONE, 7 (10). e46735. ISSN 1932-6203 doi: 10.1371/journal.pone.0046735

McNeish, A.J., Roux, B.T., Aylett, S.-B., Van Den Brink, A.M. and Cottrell, G.S. (2012) Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries. British Journal of Pharmacology, 167 (8). pp. 1679-1690. ISSN 1476-5381 doi: 10.1111/j.1476-5381.2012.02129.x

Mi, S., Chen, B., Wright, B. and Connon, C. J. (2010) Plastic compression of a collagen gel forms a much improved scaffold for ocular surface tissue engineering over conventional collagen gels. Journal of Biomedical Materials Research Part A, 95A (2). pp. 447-453. ISSN 1549-3296 doi: 10.1002/jbm.a.32861

Mi, S., David, A. L., Chowdhury, B., Jones, R. R., Hamley, I., Squires, A. and Connon, C. J. (2012) Tissue engineering a fetal membrane. Tissue Engineering Part A, 18 (3-4). pp. 373-381. ISSN 2152-4955 doi: 10.1089/ten.tea.2011.0194

Mi, S., Chen, B., Wright, B. and Connon, C. J. (2010) Ex Vivo Construction of an Artificial Ocular Surface by Combination of Corneal Limbal Epithelial Cells and a Compressed Collagen Scaffold Containing Keratocytes. Tissue Engineering, 16 (6). pp. 2091-2100. ISSN 1937-3341 doi: 10.1089/ten.TEA.2009.0748

Mi, S., Khutoryanskiy, V. V., Jones, R. R., Zhu, X., Hamley, I. W. and Connon, C. J. (2011) Photochemical cross-linking of plastically compressed collagen gel produces an optimal scaffold for corneal tissue engineering. Journal of Biomedical Materials Research Part A, 99A (1). pp. 1-8. ISSN 1549-3296 doi: 10.1002/jbm.a.33152

Morrison, P. W.J., Connon, C. J. and Khutoryanskiy, V. V. (2013) Cyclodextrin-mediated enhancement of riboflavin solubility and corneal permeability. Molecular Pharmaceutics, 10 (2). pp. 756-762. ISSN 1543-8392 doi: 10.1021/mp3005963

Oikonomopoulou, K., Hansen, K. K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S. I., Scarisbrick, I., Andrade-Gordon, P., Cottrell, G. S., Bunnett, N. W., Diamandis, E. P. and Hollenberg, M. D. (2006) Proteinase-activated receptors, targets for kallikrein signaling. The Journal of Biological Chemistry, 281 (43). pp. 32095-32112. ISSN 1083-351X doi: 10.1074/jbc.M513138200

Padilla, B. E., Cottrell, G. S., Roosterman, D., Pikios, S., Muller, L., Steinhoff, M. and Bunnett, N. W. (2007) Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. Journal of Cell Biology, 179 (5). pp. 981-997. ISSN 0021-9525 doi: 10.1083/jcb.200704053

Patani, R., Lewis, P. A., Trabzuni, D., Puddifoot, C. A., Wyllie, D. J. A., Walker, R., Smith, C., Hardingham, G. E., Weale, M., Hardy, J., Chandran, S. and Ryten, M. (2012) Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. Journal of Neurochemistry, 122 (4). pp. 738-751. ISSN 0022-3042 doi: 10.1111/j.1471-4159.2012.07825.x

Patel, N. A., Weston, S. E., Constanti, A., Halliwell, J. V. and Whalley, B. J. (2007) Cholinergic modulation of intrinsic fibre-evoked excitatory transmission contains a nicotinic component in immature but not adult rat piriform cortex, in vitro. Neuroscience Letters, 425 (1). pp. 43-48. ISSN 0304-3940 doi: 10.1016/j.neulet.2007.08.005

Peacey, E., Miller, C. C., Dunlop, J. and Rattray, M. (2009) The four major N- and C-terminal splice variants of the excitatory amino acid transporter GLT-1 form cell surface homomeric and heteromeric assemblies. Molecular Pharmacology, 75 (5). pp. 1062-1073. ISSN 1521-0111

Rainey-Smith, S. R., Andersson, D. A., Williams, R. J. and Rattray, M. (2010) Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration. Journal of Neurochemistry, 113 (3). pp. 692-703. ISSN 0022-3042 doi: 10.1111/j.1471-4159.2010.06634.x

Rainey-Smith, S., Schroetke, L.W., Bahia, P., Fahmi, A., Skilton, R., Spencer, J.P.E., Rice-Evans, C., Rattray, M. and Williams, R.J. (2008) Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. Neuroscience Letters, 438 (1). pp. 29-33. ISSN 0304-3940 doi: 10.1016/j.neulet.2008.04.056

Rattray, M. (2012) New insights on regulation of LMTK2, a membrane kinase integrating pathways central to neurodegeneration. Journal of Neurochemistry. doi: 10.1111/j.1471-4159.2012.07654.x (In Press)

Rattray, M. (2005) Technology evaluation: Colostrinin (ReGen). Current Opinion in Molecular Therapeutics, 7 (1). pp. 78-84. ISSN 1464-8431

Rattray, M. and Bendotti, C. (2006) Does excitotoxic cell death of motor neurons in ALS arise from glutamate transporter and glutamate receptor abnormalities? Experimental Neurology, 201 (1). pp. 15-23. ISSN 0014-4886 doi: 10.1016/j.expneurol.2006.05.001

Reed, D. E., Barajas-Lopez, C., Cottrell, G. S., Velazquez-Rocha, S., Dery, O., Grady, E. F., Bunnett, N. W. and Vanner, S. J. (2003) Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons. Journal of Physiology, 547 (2). pp. 531-542. ISSN 0022-3751 doi: 10.1113/jphysiol.2002.032011

Rendeiro, C., Vauzour, D., Kean, R. J., Butler, L. T., Rattray, M., Spencer, J. P. E. and Williams, C. M. (2012) Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology, 223 (3). pp. 319-330. ISSN 0033-3158 doi: 10.1007/s00213-012-2719-8

Roosterman, D., Cottrell, G. S., Padilla, B. E., Muller, L., Eckman, C. B., Bunnett, N. W. and Steinhoff, M. (2007) Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Proceedings of the National Academy of Sciences of the United States of America, 104 (28). pp. 11838-11843. ISSN 0027-8424 doi: 10.1073/pnas.0701910104

Roosterman, D., Cottrell, G. S., Schmidlin, F., Steinhoff, M. and Bunnett, N. W. (2004) Recycling and resensitization of the neurokinin 1 receptor: influence of agonist concentration and Rab GTPases. The Journal of Biological Chemistry, 279 (29). pp. 30670-30679. ISSN 1083-351X doi: 10.1074/jbc.M402479200

Roosterman, D., Kreuzer, O. J., Brune, N., Cottrell, G. S., Bunnett, N. W., Meyerhof, W. and Steinhoff, M. (2007) Agonist-induced endocytosis of rat somatostatin receptor 1. Endocrinology, 148 (3). pp. 1050-1058. ISSN 1945-7170 doi: 10.1210/en.2006-1600

Schroeter, H., Bahia, P., Spencer, J.P.E., Sheppard, O., Rattray, M., Cadenas, E., Rice-Evans, C. and Williams, R.J. (2007) (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. Journal of Neurochemistry, 101 (6). pp. 1596-1606. ISSN 0022-3042 doi: 10.1111/j.1471-4159.2006.04434.x

Spilsbury, A., Vauzour, D., Spencer, J. P. and Rattray, M. (2012) Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations. Biochemical and Biophysical Research Communications, 418. pp. 578-583. ISSN 0006-291X doi: 10.1016/j.bbrc.2012.01.081

Spyridon, M., Moraes, L. A., Jones, C. I., Sage, T., Sasikumar, P., Bucci, G. and Gibbins, J. M. (2011) LXR as a novel antithrombotic target. Blood, 117 (21). pp. 5751-5761. ISSN 1528-0020 doi: 10.1182/blood-2010-09-306142

Stephens, G. J. (2009) G-protein-coupled-receptor-mediated presynaptic inhibition in the cerebellum. Trends in Pharmacological Sciences, 30 (8). 421-430 . ISSN 01656147 doi: 10.1016/j.tips.2009.05.008

Suchak, S., Baloyianni, N., Perkinton, M., Williams, R., Meldrum, B. and Rattray, M. (2003) The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings. Journal of Neurochemistry, 84 (3). pp. 522-532. ISSN 0022-3042 doi: 10.1046/j.1471-4159.2003.01553.x

Tortarolo, M., Crossthwaite, A.J., Conforti, L., Spencer, J.P.E., Williams, R.J. , Bendotti, C. and Rattray, M. (2004) Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress. Journal of Neurochemistry, 88 (2). pp. 481-493. ISSN 0022-3042 doi: 10.1046/j.1471-4159.2003.02208.x

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andre, E., Patacchini, R., Cottrell, G. S., Gatti, R., Basbaum, A. I., Bunnett, N. W., Julius, D. and Geppetti, P. (2007) 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proceedings of the National Academy of Sciences of the United States of America, 104 (33). pp. 13519-13524. ISSN 0027-8424 doi: 10.1073/pnas.0705923104

Vauzour, D., Spilsbury, A., Vafeiadou, K., Rattray, M. and Spencer, J. (2012) Modulation of neuroinflammation by dietary flavonoids. In: Gemma, C. (ed.) Neuroinflammation: Pathogenesis, Mechanisms and Management. Nova. ISBN 9781619424623 (In Press)

Vogl, C., Mochida, S., Wolff, C., Whalley, B. and Stephens, G. (2012) The SV2A ligand levetiracetam inhibits presynaptic Ca2+ channels via an intracellular pathway. Molecular Pharmacology, 82 (2). pp. 199-208. ISSN 1521-0111 doi: 10.1124/mol.111.076687

Wang, X., Horswill, J. G., Whalley, B. J. and Stephens, G. J. (2011) Effects of the Allosteric Antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 Receptor Modulation in the Cerebellum. Molecular Pharmacology, 79 (4). pp. 758-767. ISSN 1521-0111 doi: 10.1124/mol.110.068197

Warwick, K., Xydas, D., Nasuto, S. J., Becerra, V. M., Hammond, M. W., Downes, J., Marshall, S. and Whalley, B. J. (2010) Controlling a mobile robot with a biological brain. Defence Science Journal, 60 (1). pp. 5-14. ISSN 0011-748X

Weston, S. E., Williamson, E. M., Constanti, A., Stephens, G. J. and Whalley, B. J. (2006) Tetrahydrocannabivarin exhibits anticonvulsant effects in a piriform cortical brain slice model of epileptiform activity. In: British Pharmacological Society Winter Meeting 2006.

Whalley, B. J. and Constanti, A. (2006) Developmental changes in presynaptic muscarinic modulation of excitatory and inhibitory neurotransmission in rat piriform cortex in vitro: relevance to epileptiform bursting susceptibility. Neuroscience, 140 (3). pp. 939-956. ISSN 0306-4522 doi: 10.1016/j.neuroscience.2006.02.046

Whalley, B. J., Postlethwaite, M. and Constanti, A. (2005) Further characterization of muscarinic agonist-induced epileptiform bursting activity in immature rat piriform cortex, in vitro. Neuroscience, 134 (2). pp. 549-566. ISSN 0306-4522 doi: 10.1016/j.neuroscience.2005.04.018

Whalley, B. J., Stephens, G. J. and Constanti, A. (2009) Investigation of the effects of the novel anticonvulsant compound carisbamate(RWJ-333369) on rat piriform cortical neurones in vitro. British Journal of Pharmacology, 156 (6). pp. 994-1008. ISSN 0007-1188 doi: 10.1111/j.1476-5381.2008.00110.x

Whalley, B. J., Wilkinson, J. D., Williamson, E. M. and Constanti, A. (2004) A novel component of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in vitro. Neuroscience Letters, 365 (1). pp. 58-63. ISSN 0304-3940 doi: 10.1016/j.neulet.2004.04.044

Wilkinson, J.D., Whalley, B. J., Baker, D., Pryce, G., Constanti, A., Gibbons, S. and Williamson, E. M. (2003) Medicinal cannabis: is delta9-tetrahydrocannabinol necessary for all its effects? Journal of Pharmacy and Pharmacology, 55 (12). pp. 1687-1694. ISSN 0022-3573 doi: DOI:10.1211/0022357022304

Wright, B., Mi, S. and Connon, C. J. (2012) Towards the use of hydrogels in the treatment of limbal stem cell deficiency. Drug Discovery Today, 18 (1-2). pp. 79-86. ISSN 1359-6446 doi: 10.1016/j.drudis.2012.07.012

Wright, B., Cave, R. A., Cook, J. P., Khutoryanskiy, V. V., Mi, S., Chen, B., Leyland, M. and Connon, C. J. (2012) Enhanced viability of corneal epithelial cells for efficient transport/storage using a structurally-modified calcium alginate hydrogel. Regenerative Medicine, 7 (3). pp. 295-307. ISSN 1746-076X doi: 10.2217/rme.12.7

Yang, L. and Stephens, G. J. (2009) Effects of neuropathy on high-voltage-activated Ca2+ current in sensory neurones. Cell Calcium, 46 (4). 248-256 . ISSN 01434160 doi: 10.1016/j.ceca.2009.08.001

Yuill, K. H., McNeish, A., Kansui, Y., Garland, C. J. and Dora , K. A. (2010) Nitric oxide suppresses cerebral vasomotion by sGC-independent effects on ryanodine receptors and voltage-gated calcium channels. Journal of Vascular Research, 47 (2). pp. 93-107. ISSN 1018-1172 doi: 10.1159/000235964