Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytesBicknell, K. A., Coxon, C. H. and Brooks, G. (2004) Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes. The Biochemical Journal, 382 (2). pp. 411-6. ISSN 1470-8728 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. Official URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... Abstract/SummaryRepair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.
Deposit Details University Staff: Request a correction | Centaur Editors: Update this record |
Lists
Lists
