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Discovery of a second citric acid cycle complex

Roosterman, D. and Cottrell, G. S. ORCID: (2023) Discovery of a second citric acid cycle complex. Heliyon, 9 (5). e15968. ISSN 24058440

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To link to this item DOI: 10.1016/j.heliyon.2023.e15968


Together, Nobel Prize honoured work, mathematics, physics and the laws of nature have drawn a concept of clockwise cycling carboxylic acids in Krebs' Citric Acid Cycle. A Citric Acid Cycle complex is defined by specific substrate, product and regulation. Recently, the Citric Acid Cycle 1.1 complex was introduced as an NAD+-regulated cycle with the substrate, lactic acid and the product, malic acid. Here, we introduce the concept of the Citric Acid Cycle 2.1 complex as an FAD-regulated cycle with the substrate, malic acid and the products, succinic acid or citric acid. The function of the Citric Acid Cycle 2.1 complex is to balance stress situations within the cell. We propose that the biological function of Citric Acid Cycle 2.1 in muscles is to accelerate recovery of ATP; whereas in white tissue adipocytes our testing of the theoretical concept led to the storage of energy as lipids.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:112028
Uncontrolled Keywords:Citric acid cycle, Pyruvate dehydrogenase complex, Proton-linked monocarboxylate transporter


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