Accessibility navigation


Evaluation of two and three fluid nozzle spray drying to prepare co-crystals of salicylic acid and caffeine with improved physicochemical propertiess

Hibbard, T., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155 and Al-Obaidi, H. ORCID: https://orcid.org/0000-0001-9735-0303 (2023) Evaluation of two and three fluid nozzle spray drying to prepare co-crystals of salicylic acid and caffeine with improved physicochemical propertiess. Journal of Drug Delivery Science and Technology, 89. 105073. ISSN 1773-2247

[img]
Preview
Text (Open Access) - Published Version
· Available under License Creative Commons Attribution.
· Please see our End User Agreement before downloading.

3MB

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1016/j.jddst.2023.105073

Abstract/Summary

Formation of co-crystals using spray drying remains a challenging task due to the rapid nature of the process and the possible impact of solvents on the formation of the co-crystals. The purpose of this work was to generate co- crystals via two-fluid and three-fluid nozzle spray drying using the model system of salicylic acid and caffeine (SAL-CAF). The prepared co-crystal showed a strong tendency to form through spray drying, from a variety of feedstock compositions and through both two-fluid and three-fluid drying methods. Powder X-ray diffraction, Fourier - Transform infrared spectroscopy and differential scanning calorimetry were used to characterise the spray dried powders through comparison to the reported crystal structure and SAL-CAF formed through milling. All spray dried powders showed good agreement to the reported crystal structure but with an additional phase present, determined as the β-polymorph of caffeine. This additional phase was present at different proportions corresponding to the solvent, feedstock concentration and method used. For the three-fluid nozzle method, the feedstock composition was shown to have a large influence on the proportion of co-crystal in the final sample and all three-fluid nozzle samples showed reduced crystallinity compared to the two-fluid nozzle method. The spray dried co-crystals showed resistance to stress conditions over a period of four months and remained detectable following a tableting process. Spray drying is a suitable technique for the preparation of the SAL-CAF co-crystal and with further optimisation of process parameters may be equivalent or superior to milling.

Item Type:Article
Refereed:No
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Thermal Analysis (CAF)
Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Xray (CAF)
ID Code:113737
Publisher:Elsevier

Downloads

Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation