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Development of tyrosinase labile protecting groups for amines

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Osborn, H.M.I. ORCID: https://orcid.org/0000-0002-0683-0457 and Williams, N.A.O. (2004) Development of tyrosinase labile protecting groups for amines. Organic Letters, 6 (18). pp. 3111-3113. ISSN 1523-7060

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To link to this item DOI: 10.1021/ol040042i

Abstract/Summary

The development of two novel protecting groups for amines is described. Thus, a range of amines have been converted to ureas, and the deprotection of these upon exposure to mushroom tyrosinase (E.C. 1.14.18.1) has been demonstrated.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11541
Uncontrolled Keywords:PRODRUG THERAPY MDEPT, MALIGNANT-MELANOMA, TARGETED TREATMENT
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