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Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity

Spencer, J. P. E. ORCID:, El Mohsen, M. M. A. and Rice-Evans, C. (2004) Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity. Archives of Biochemistry and Biophysics, 423 (1). pp. 148-161. ISSN 0003-9861

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To link to this item DOI: 10.1016/


Flavonoids have been proposed to act as beneficial agents in a multitude of disease states, including cancer, cardiovascular disease, and neurodegenerative disorders. The biological effect of these polyphenols and their in vivo circulating metabolites will ultimately depend on the extent to which they associate with cells, either by interactions at the membrane or more importantly their uptake. This review summarises the current knowledge on the cellular uptake of flavonoids and their metabolites with particular relevance to further intracellular metabolism and the generation of potential new bioactive forms. Uptake and metabolism of the circulating forms of flavanols, flavonols, and flavanones into cells of the skin, the brain, and cancer cells is reviewed and potential biological relevance to intracellular formed metabolites is discussed.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:12971
Uncontrolled Keywords:flavonoid, cell uptake, metabolism, bioactivity, low-density-lipoprotein, polyphenol (-)-epigallocatechin-3-gallate treatment, udp-glucuronosyltransferase ugt1a1, performance liquid-chromatography, multidrug-resistance protein, neuronal signal-transduction, induced lipid-peroxidation, human liver-microsomes, in-vivo metabolites, blood-brain-barrier, Animals Central Nervous System/metabolism, Cytochrome P-450 Enzyme System/metabolism, Flavonoids/*metabolism, Humans plasms/metabolism, Oxidation-Reduction, Skin/metabolism, Sulfhydryl Compounds/metabolism

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