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Combination therapy for envenomation

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University of Reading (2026) Combination therapy for envenomation. IN202514062317 A1. doi: IN202514062317 A1

Abstract/Summary

The present invention relates to a combination composition or kit for 5 the prevention or amelioration of the effects of envenomation, such as that caused by snake venom. The composition comprises a tyrosine kinase inhibitor in combination with at least one of a phospholipase A2 (PLA2) inhibitor and a matrix metalloprotease (MMP) inhibitor. In preferred embodiments, the tyrosine kinase inhibitor is nilotinib, the PLA2 inhibitor is varespladib, and the MMP inhibitor is marimastat. The combination may optionally be administered with antivenom and formulated as a pharmaceutical composition for therapeutic use.

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Item Type Patent
URI https://centaur.reading.ac.uk/id/eprint/130477
Identification Number/DOI IN202514062317 A1
Divisions Life Sciences > School of Biological Sciences > Biomedical Sciences
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
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