Accessibility navigation

Dietary-based gut flora modulation against Clostridium difficile onset

Gougoulias, C., Tuohy, K.M. and Gibson, G.R. (2007) Dietary-based gut flora modulation against Clostridium difficile onset. Food Science and Technology Bulletin: Functional Foods, 4 (4). pp. 31-41. ISSN 1476-2137

Text - Published Version
· Please see our End User Agreement before downloading.


It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

Official URL:


Clostridium difficile infection is a frequent complication of antibiotic therapy in hospitalised patients, which today is attracting more attention than ever and has led to its classification as a 'superbug'. Disruption of the composition of the intestinal microflora following antibiotic treatment is an important prerequisite for overgrowth of C. difficile and the subsequent development of an infection. Treatment options for antibiotic-associated diarrhoea and C. difficile-induced colitis include administration of specific antibiotics (e.g. vancomycin), which often leads to high relapse rates. More importantly, both the rate and severity of C. difficile-associated diseases are increasing, with new epidemic strains of C. difficile often implicated. For the prevention and treatment of antibiotic-associated diarrhoea and C. difficile infection, several probiotic bacteria such as selected strains of lactobacilli (especially Lactobacillus rhamnosus GG), Bifidobacterium longum, and Enterococcus faecium and the non-pathogenic yeast Saccharomyces boulardii have been used. Controlled trials indicate a benefit of S. boulardii and L. rhamnosus GG as therapeutic agents when used as adjuncts to antibiotics. However, the need for more well designed controlled trials with probiotics is explicit.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:13360
Uncontrolled Keywords:probiotics, Clostridium difficile, diarrhoea
Publisher:IFIS Publishing
Publisher Statement:Copyright IFIS –


Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation