Genistein reverses changes of the proteome induced by oxidized-LDL in EA center dot hy 926 human endothelial cellsFuchs, D., Erhard, P., Turner, R., Rimbach, G., Daniel, H. and Wenzel, U. (2005) Genistein reverses changes of the proteome induced by oxidized-LDL in EA center dot hy 926 human endothelial cells. Journal of Proteome Research, 4 (2). pp. 369-376. ISSN 1535-3893 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1021/pr049820r Abstract/SummaryEndothelial cells are primary targets for pro-atherosclerotic stressors such as oxidized LDL (ox-LDL). The isoflavone genistein, on the other hand, is suggested to prevent a variety of processes underlying atherosclerosis and cardiovascular diseases. By analyzing the proteome of EA(.)hy 926 endothelial cells, here we show, that genistein reverses the ox-LDL-induced changes of the steady-state levels of several proteins involved in atherosclerosis. These alterations caused by genistein are functionally linked to the inhibition of ox-LDL induced apoptosis.
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