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Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats

File, S. E., Hartley, D. E., Alom, N. and Rattray, M. (2003) Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats. Neuroscience Letters, 338 (2). pp. 135-138. ISSN 0304-3940

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To link to this item DOI: 10.1016/S0304-3940(02)01391-5


Adult male hooded Lister rats were either fed a diet containing 150 microg/g soya phytoestrogens or a soya-free diet for 18 days. This concentration of phytoestrogens should have been sufficient to occupy the oestrogen-beta, but not the oestrogen-alpha, receptors. Using in situ hybridisation, significant reductions were found in brain-derived neurotrophic factor (BDNF) mRNA expression in the CA3 and CA4 region of the hippocampus and in the cerebral cortex in the rats fed the diet containing phytoestrogens, compared with those on the soya-free diet. No changes in glutamic acid decarboxylase-67 or glial fibrillary acidic protein mRNA were found. This suggests a role for oestrogen-beta receptors in regulating BDNF mRNA expression.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:15731
Uncontrolled Keywords:Animals: Brain-Derived Neurotrophic Factor; /*biosynthesis/genetics; Cerebral Cortex/*drug effects/metabolism; Estrogens; Non-Steroidal/*pharmacology; Hippocampus/*drug effects/metabolism: In Situ Hybridization *Isoflavones; Male Phytoestrogens; Plant Preparations; RNA; Messenger/*biosynthesis; Rats; *Soybeans

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