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Aldol reaction of butane-2,3-diacetal protected methyl glycerate

Fern, S. E., Heath, P. and Cobb, A. J. A. (2011) Aldol reaction of butane-2,3-diacetal protected methyl glycerate. Tetrahedron: Asymmetry, 22 (2). pp. 149-152. ISSN 0957-4166

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To link to this item DOI: 10.1016/j.tetasy.2011.01.004


The addition of aldehydes to butane-2,3-diacetal has been investigated. The reaction was shown to be both regioselective and diastereoselective by 1H NMR spectroscopy. The configuration of the newly formed stereocenter was determined by Mosher’s ester analysis.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
ID Code:16164
Additional Information:Dedicated to Professor Steven V. Ley CBE FRS on the occasion of his 65th birthday

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