The role of 80K/MARCKS, a specific substrate of protein kinase C, in cell growth and tumour progressionBrooks, G. (1994) The role of 80K/MARCKS, a specific substrate of protein kinase C, in cell growth and tumour progression. Pigment Cell Research, 7 (6). pp. 451-457. ISSN 0893-5785 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1111/j.1600-0749.1994.tb00074.x Abstract/SummarySince its discovery more than a decade ago [Wu et al., 1982; Rozengurt et al., 1983], the 80-87 kDa myristoylated a lanine-rich C-kinase substrate (80K/MARCKS) protein has attracted a great deal of attention from researchers interested in cell growth and tumour progression. However, despite its ubiquitous distribution, a definitive functional role for 80K/MARCKS has not been found. The purpose of this review is to describe the properties, distribution and regulation of 80K/MARCKS and to discuss some of the most recent findings, both from our laboratory and from others, that have suggested a functional role for this protein in modulating cell growth and tumour progression. Furthermore, I will present data from our laboratory that implicates 80K/MARCKS as a novel tumour suppressor in cells of melanocyte origin.
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