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Theory and generalization of Monte Carlo models of the BOLD signal source

Martindale, J., Kennerley, A. J., Johnston, D., Zheng, Y. ORCID: and Mayhew, J. E. (2008) Theory and generalization of Monte Carlo models of the BOLD signal source. Magnetic Resonance in Medicine, 59 (3). pp. 607-618. ISSN 1522-2594

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To link to this item DOI: 10.1002/mrm.21512


The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra- and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look-up-table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics. Magn Reson Med, 2008. © 2008 Wiley-Liss, Inc.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences > Department of Bio-Engineering
ID Code:33482
Uncontrolled Keywords:Monte Carlo simulations; biophysical model; BOLD; hemodynamics; fMRI

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