Accessibility navigation


Oligonucleotide compound and method for treating nidovirus infections

Sarepta Pharmaceuticals, The Scripps Research Institute (2014) Oligonucleotide compound and method for treating nidovirus infections. . (USOO8759307B2)

[img]
Preview
Text (US Patent - complete) - Published Version
· Please see our End User Agreement before downloading.

2MB

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

Official URL: http://www.google.com/patents/US8759307

Abstract/Summary

A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5′ leader region of the positive-strand viral genome and negative-strand 3′ subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.

Item Type:Patent
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:37088
Additional Information:US Patent 8,759,307
Publisher:Google Patents

Downloads

Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation