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Oligonucleotide compound and method for treating nidovirus infections

Sarepta Pharmaceuticals, The Scripps Research Institute (2014) Oligonucleotide compound and method for treating nidovirus infections. . (USOO8759307B2)

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A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5′ leader region of the positive-strand viral genome and negative-strand 3′ subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.

Item Type:Patent
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:37088
Additional Information:US Patent 8,759,307
Publisher:Google Patents


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