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Does form meet function in the coronavirus replicative organelle?

Neuman, B. W., Angelini, M. M. and Buchmeier, M. J. (2014) Does form meet function in the coronavirus replicative organelle? Trends in Microbiology, 22 (11). pp. 642-647. ISSN 0966-842X

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To link to this item DOI: 10.1016/j.tim.2014.06.003


If we use the analogy of a virus as a living entity, then the replicative organelle is the body where its metabolic and reproductive activities are concentrated. Recent studies have illuminated the intricately complex replicative organelles of coronaviruses, a group that includes the largest known RNA virus genomes. This review takes a virus-centric look at the coronavirus replication transcription complex organelle in the context of the wider world of positive sense RNA viruses, examining how the mechanisms of protein expression and function act to produce the factories that power the viral replication cycle.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:37090
Uncontrolled Keywords:RNA virus replication, membrane rearrangement, replicative organelle, virus factory
Publisher:Cell Press

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