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Synthesis of linked heterocycles via use of bis-acetylenic compounds

Smith, C. ORCID: https://orcid.org/0000-0002-5911-5836, Tchabanenko, K., Adlington, R.M. and Baldwin, J.E. (2006) Synthesis of linked heterocycles via use of bis-acetylenic compounds. Tetrahedron Letters, 47 (19). pp. 3209-3212. ISSN 0040-4039

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To link to this item DOI: 10.1016/j.tetlet.2006.03.052

Abstract/Summary

Linked bis-pyrazoles, a pyrazolyl-isoxazole, a pyrazolyl-pyrimidine and a pyrazolyl-triazole were synthesized starting with commercially available 1,4-bis(trimethylsilyl)-1,3-butadiyne 1 or readily available bis-acetylenic diketone 22. A stepwise approach based on the use of 1 allowed the synthesis of nonsymmetrically substituted bis-pyrazoles and linked heterocycles with two different cores whereas a symmetric approach based on the use of 22 allowed a very short synthesis of symmetric bis-pyrazoles.

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
ID Code:37117
Publisher:Elsevier

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