Genetic, structural, and molecular insights into the function of ras of complex proteins domainsCiviero, L., Dihanich, S., Lewis, P. A. and Greggio, E. (2014) Genetic, structural, and molecular insights into the function of ras of complex proteins domains. Chemistry and Biology, 21 (7). pp. 809-818. ISSN 1074-5521
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1016/j.chembiol.2014.05.010 Abstract/SummaryRas of complex proteins (ROC) domains were identified in 2003 as GTP binding modules in large multidomain proteins from Dictyostelium discoideum. Research into the function of these domains exploded with their identification in a number of proteins linked to human disease, including leucine-rich repeat kinase 2 (LRRK2) and death-associated protein kinase 1 (DAPK1) in Parkinson’s disease and cancer, respectively. This surge in research has resulted in a growing body of data revealing the role that ROC domains play in regulating protein function and signaling pathways. In this review, recent advances in the structural informa- tion available for proteins containing ROC domains, along with insights into enzymatic function and the integration of ROC domains as molecular switches in a cellular and organismal context, are explored.
Download Statistics DownloadsDownloads per month over past year Altmetric Funded Project Deposit Details University Staff: Request a correction | Centaur Editors: Update this record |
Lists
Lists
