Accessibility navigation


Diverse mechanisms underlying the regulation of ion channels by carbon monoxide

Peers, C., Boyle, J. P., Scragg, J. L., Dallas, M. ORCID: https://orcid.org/0000-0002-5190-0522, Al-Owais, M. M., Hettiarachichi, N. T., Elies, J., Johnson, E., Gamper, N. and Steele, D. (2015) Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. British Journal of Pharmacology, 172 (6). pp. 1546-1556. ISSN 0007-1188

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1111/bph.12760

Abstract/Summary

Carbon monoxide (CO) is firmly established as an important, physiological signalling molecule as well as a potent toxin. Through its ability to bind metal-containing proteins, it is known to interfere with a number of intracellular signalling pathways, and such actions can account for its physiological and pathological effects. In particular, CO can modulate the intracellular production of reactive oxygen species, NO and cGMP levels, as well as regulate MAPK signalling. In this review, we consider ion channels as more recently discovered effectors of CO signalling. CO is now known to regulate a growing number of different ion channel types, and detailed studies of the underlying mechanisms of action are revealing unexpected findings. For example, there are clear areas of contention surrounding its ability to increase the activity of high conductance, Ca2+ -sensitive K+ channels. More recent studies have revealed the ability of CO to inhibit T-type Ca2+ channels and have unveiled a novel signalling pathway underlying tonic regulation of this channel. It is clear that the investigation of ion channels as effectors of CO signalling is in its infancy, and much more work is required to fully understand both the physiological and the toxic actions of this gas. Only then can its emerging use as a therapeutic tool be fully and safely exploited.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:38202
Uncontrolled Keywords:carbon monoxide; haem oxygenase; ion channel; signal transduction; gasotransmitter; nitric oxide; reactive oxygen species; mitochondria; cyclic nucleotides
Publisher:Nature Publishing Group

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation