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Enhanced MALDI MS sensitivity by weak base additives and glycerol sample coating

Cramer, R. ORCID:, Karas, M. and Jaskolla, T.W. (2013) Enhanced MALDI MS sensitivity by weak base additives and glycerol sample coating. Analytical Chemistry, 86 (1). pp. 744-751. ISSN 0003-2700

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To link to this item DOI: 10.1021/ac403228d


The concept of rationally designing MALDI matrices has been extended to the next “whole sample” level. These studies have revealed some unexpected and exploitable insights in improving MALDI sensitivity. It is shown that (i) additives which only provide additional laser energy absorption are best to be avoided; (ii) the addition of proton donors in the form of protonated weak bases can be highly beneficial; (iii) the addition of glycerol for coating crystalline samples is highly recommended. Overall, analytical sensitivity has been significantly increased compared to the current “gold” standards in MALDI MS, and new insights into the mechanisms and processes of MALDI have been gained.

Item Type:Article
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:38486
Publisher:American Chemical Society

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