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Asymmetric organocatalytic synthesis of cyclopentane γ-nitroketones

Al-Ani, W., Shankland, K. and Cobb, A. J. A. (2016) Asymmetric organocatalytic synthesis of cyclopentane γ-nitroketones. Synlett, 27 (1). pp. 17-20. ISSN 0936-5214

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To link to this item DOI: 10.1055/s-0035-1560504


This paper describes the use of bifunctional thiourea catalysts in the intramolecular reaction of a nitronate with conjugated ketones to generate the corresponding γ-nitroketones. In contrast to our previous studies in this area, we obtained the cis-functionalized systems as the major diastereoisomers in good yields and reasonable selectivities.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
ID Code:44844
Additional Information:Invited submission to the Prof Steve Ley 70th Birthday celebrations


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