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Changes in physical activity following a genetic-based internet-delivered personalized intervention: randomized controlled trial (Food4Me)

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Marsaux, C. F. M., Celis-Morales, C., Livingstone, K. M., Fallaize, R., Kolossa, S., Hallmann, J., San-Cristobal, R., Navas-Carretero, S., O'Donovan, C. B., Woolhead, C., Forster, H., Moschonis, G., Lambrinou, C.-P., Surwillo, A., Godlewska, M., Hoonhout, J., Goris, A., Macready, A. L. ORCID: https://orcid.org/0000-0003-0368-9336, Walsh, M. C., Gibney, E. R. , Brennan, L., Manios, Y., Traczyk, I., Drevon, C. A., Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455, Martinez, J. A., Daniel, H., Gibney, M. J., Mathers, J. C. and Saris, W. H. M. (2016) Changes in physical activity following a genetic-based internet-delivered personalized intervention: randomized controlled trial (Food4Me). Journal of Medical Internet Research, 18 (2). e30. ISSN 1438-8871

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To link to this item DOI: 10.2196/jmir.5198

Abstract/Summary

Background: There is evidence that physical activity (PA) can attenuate the influence of the fat mass- and obesity-associated (FTO) genotype on the risk to develop obesity. However, whether providing personalized information on FTO genotype leads to changes in PA is unknown. Objective: The purpose of this study was to determine if disclosing FTO risk had an impact on change in PA following a 6-month intervention. Methods: The single nucleotide polymorphism (SNP) rs9939609 in the FTO gene was genotyped in 1279 participants of the Food4Me study, a four-arm, Web-based randomized controlled trial (RCT) in 7 European countries on the effects of personalized advice on nutrition and PA. PA was measured objectively using a TracmorD accelerometer and was self-reported using the Baecke questionnaire at baseline and 6 months. Differences in baseline PA variables between risk (AA and AT genotypes) and nonrisk (TT genotype) carriers were tested using multiple linear regression. Impact of FTO risk disclosure on PA change at 6 months was assessed among participants with inadequate PA, by including an interaction term in the model: disclosure (yes/no) × FTO risk (yes/no). Results: At baseline, data on PA were available for 874 and 405 participants with the risk and nonrisk FTO genotypes, respectively. There were no significant differences in objectively measured or self-reported baseline PA between risk and nonrisk carriers. A total of 807 (72.05%) of the participants out of 1120 in the personalized groups were encouraged to increase PA at baseline. Knowledge of FTO risk had no impact on PA in either risk or nonrisk carriers after the 6-month intervention. Attrition was higher in nonrisk participants for whom genotype was disclosed (P=.01) compared with their at-risk counterparts. Conclusions: No association between baseline PA and FTO risk genotype was observed. There was no added benefit of disclosing FTO risk on changes in PA in this personalized intervention. Further RCT studies are warranted to confirm whether disclosure of nonrisk genetic test results has adverse effects on engagement in behavior change.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Food Chain and Health
Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Life Sciences > School of Agriculture, Policy and Development > Department of Agri-Food Economics & Marketing
Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Life Sciences > School of Psychology and Clinical Language Sciences > Nutrition and Health
ID Code:54550
Uncontrolled Keywords:FTO; physical activity; personalized intervention; randomized controlled trial; genetic testing; disclosure; behavior change; Web based
Publisher:JMIR Publications
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