Accessibility navigation

Anti-leishmanial activity of Ni(ii), Pd(ii) and Pt(ii) β-oxodithioester complexes

Yadav, M. K., Rajput, G., Srivastava, K., Singh, R. K., Mishra, R., Drew, M. and Singh, N. (2015) Anti-leishmanial activity of Ni(ii), Pd(ii) and Pt(ii) β-oxodithioester complexes. New Journal of Chemistry, 39 (8). pp. 6358-6366. ISSN 1369-9261

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1039/c5nj00765h


New functionalized planar β-oxodithioester cis-chelate complexes, [M(L)2] (L = L1, methyl-3-hydroxy-3-(p-bromophenyl)-2-propenedithioate, M = Ni 1, Pd 5, Pt 9; L2, methyl-3-hydroxy-3-(p-fluorophenyl)-2-propenedithioate, Ni 2, Pd 6, Pt 10; L3, methyl-3-hydroxy-3-(naphthyl)-2-propenedithioate, Ni 3, Pd 7, Pt 11; methyl-3-hydroxy-3-(p-methoxyphenyl)-2-propenedithioate, Ni 4, Pd 8, Pt 12), have been synthesized and characterized by elemental analysis, IR, UV-Vis, 1H and 13C NMR spectroscopy; the structures of 2–4, 8 and 11 have been elucidated by X-ray crystallography. In all crystal structures, the metal has four-coordinate slightly distorted square planar geometry with a cis-configuration of the ligands. These complexes have been assessed for their use as anti-leishmanial agents; 7 and 9 showed impressive anti-promastigote and anti-amastigote efficacy with IC50 values of 0.59 ± 0.10 μg mL−1, 0.56 ± 0.10 μg mL−1 and IC50 0.85 ± 0.27, 1.99 ± 0.08 μg mL−1, respectively. Cytotoxicity assays on both compounds displayed toxicity on the promastigotes but less toxicity against RAW 264.7 cell lines at different concentrations. The Pd and Pt complexes exhibit luminescent characteristics in solution, originating from the intraligand charge transfer state.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:73896
Uncontrolled Keywords:Materials Chemistry, General Chemistry, Catalysis
Publisher:Royal Society of Chemistry (RSC)

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation