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Its time: a commentary on fear extinction in the human brain using fMRI

Morriss, J., Hoare, S. and van Reekum, C. M. ORCID: (2018) Its time: a commentary on fear extinction in the human brain using fMRI. Neuroscience and Biobehavioral Reviews, 94. pp. 321-322. ISSN 0149-7634

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To link to this item DOI: 10.1016/j.neubiorev.2018.06.025


The recent meta-analysis by Fullana et al. (2018) is both timely and significant, providing a vital milestone towards understanding the neural networks involved in threat extinction in humans. Fullana et al. (2018) examined both threat extinction and recall separately using sophisticated meta-analytic methods based on raw contrast maps. Importantly, the meta-analysis highlighted a lack of consistent activation across studies for key neural "players" in the threat extinction circuit: the amygdala and ventromedial prefrontal cortex (vmPFC). In the current commentary, we highlight reasons for which this key circuitry may not have resulted from this meta-analysis, and call for a 'gold standard' in the examination of threat extinction using fMRI.

Item Type:Article
Divisions:Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
ID Code:78184


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