Accessibility navigation


A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence

Carr, R., Di Bari, L., Lo Piano, S. ORCID: https://orcid.org/0000-0002-2625-483X, Parker, D., Peacock, R. D. and Sanderson, J. M. (2012) A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence. Dalton Transactions, 41 (42). pp. 13154-13158. ISSN 1364-5447

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1039/C2DT30143A

Abstract/Summary

Reversible and selective binding of a dynamically racemic europium(III) complex to α1-acid glycoprotein and α1-antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of α1-AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated α1-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands.

Item Type:Article
Refereed:Yes
Divisions:Science > School of the Built Environment
No Reading authors. Back catalogue items
Science > School of the Built Environment > Energy and Environmental Engineering group
ID Code:90482
Publisher:Royal Society of Chemistry

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation