The sequential analysis of repeated binary responses: a score test for the case of three time pointsSooriyarachchi, M.R., Whitehead, J., Whitehead, A. and Bolland, K. (2006) The sequential analysis of repeated binary responses: a score test for the case of three time points. Statistics in Medicine, 25 (13). pp. 2196-2214. ISSN 0277-6715 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1002/sim.2339 Abstract/SummaryIn this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for stratification are discussed. Copyright © 2005 John Wiley & Sons, Ltd.
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