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Active control comparisons: the ideal trial design

Brodie, M.J. and Whitehead, J. (2006) Active control comparisons: the ideal trial design. Epilepsy Research, 68 (1). 69-73 . ISSN 0920-1211

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To link to this item DOI: 10.1016/j.eplepsyres.2005.09.025


This report describes the concept for a clinical trial that uses carbamazepine as the gold-standard active control for a study of newly diagnosed patients. The authors describe an endpoint including efficacy and tolerability, and a stopping rule that uses a series of interim analyses in order to reach a conclusion as efficiently as possible without sacrificing reliability.

Item Type:Article
Divisions:Science > School of Mathematical, Physical and Computational Sciences > Department of Mathematics and Statistics > Applied Statistics
ID Code:9479

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