Self-assembly of the cyclic lipopeptide daptomycin: spherical micelle formation does not depend on the presence of calcium chloride

Kirkham, S., Castelletto, V., Hamley, I. ORCID: https://orcid.org/0000-0002-4549-0926, Inoue, K., Rambo, R., Reza, M. and Ruokolainen, J. (2016) Self-assembly of the cyclic lipopeptide daptomycin: spherical micelle formation does not depend on the presence of calcium chloride. ChemPhysChem, 17 (14). pp. 2118-2122. ISSN 1439-7641 doi: 10.1002/cphc.201600308

Abstract/Summary

The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.

Item Type	Article
URI	https://centaur.reading.ac.uk/id/eprint/66618
Identification Number/DOI	10.1002/cphc.201600308
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Wiley
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