Article

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Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Kempster, C., Dunster, J. L. ORCID: https://orcid.org/0000-0001-8986-4902, Mitchell, J. L., Sage, T., Rawlings, S., Diaz Alonso, M. V., Shpakova, V. ORCID: https://orcid.org/0000-0002-9304-7099, Whyte, A., Dymott, L., Mark, S., Brunton, M., Batista, J., McKinney, H., Thomas, P., Downes, K., Unsworth, A. J., Ruparelia, N., McKenna, C., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2025) TRIPLE score: GPVI and CD36 expression predict a prothrombotic platelet function phenotype. Circulation Research, 136 (4). pp. 439-441. ISSN 0009-7330 doi: 10.1161/CIRCRESAHA.124.325701

Mitchell, J. L., Dunster, J. L. ORCID: https://orcid.org/0000-0001-8986-4902, Kriek, N., Unsworth, A. J., Sage, T., Mohammed, Y. M. M., De Simone, I., Taylor, K. A. ORCID: https://orcid.org/0000-0002-4599-7727, Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Ólafsson, G., Brunton, M., Mark, S., Dymott, L. D., Whyte, A., Ruparelia, N., Mckenna, C., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509 (2023) The rate of platelet activation determines thrombus size and structure at arterial shear. Journal of Thrombosis and Haemostasis, 21 (8). pp. 2248-2259. ISSN 1538-7836 doi: 10.1016/j.jtha.2023.03.044

Mitchell, J. L., Little, G., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Gaspar, R. S., Unsworth, A. J., Kriek, N., Sage, T., Stainer, A., Sangowawa, I., Morrow, G. B., Bastos, R. N., Shapiro, S., Desborough, M. J. R., Curry, N., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Whyte, C. S., Mutch, N. J. and Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509 (2023) Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. Research and Practice in Thrombosis and Haemostasis, 7 (5). 100200. ISSN 2475-0379 doi: 10.1016/j.rpth.2023.100200

Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Rawlings, S. J., Prodger, C., Kesavan, M., Lees, C., Booth, S., Cowen, L. G., Shefferd, K., Desborough, M. J., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Eyre, T. A. (2023) Pirtobrutinib results in reversible platelet dysfunction compared to ibrutinib and acalabrutinib. Haematologica, 108 (5). ISSN 1592-8721 doi: 10.3324/haematol.2022.281402

Mitchell, J. L., Khan, D., Rana, R. H., Kriek, N., Unsworth, A. J., Sage, T., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Laffan, M., Shapiro, S., Thakurta, A., Grech, H., Ramasamy, K. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2023) Multiple myeloma and its treatment contribute to increased platelet reactivity. Platelets, 34 (1). 2264940. ISSN 1369-1635 doi: 10.1080/09537104.2023.2264940

Kriek, N., Nock, S. H., Sage, T., Khalifa, B., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Mitchell, J. L., Thomson, S., McLaughlin, M. G., Jones, S., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Unsworth, A. J. ORCID: https://orcid.org/0000-0003-3809-5984 (2022) Cucurbitacins elicit anti-platelet activity via perturbation of the cytoskeleton and integrin function. Thrombosis and Haemostasis, 122 (07). pp. 1115-1129. ISSN 0340-6245 doi: 10.1055/a-1788-5322

Kempster, C., Butler, G., Kuznecova, E., Taylor, K. A. ORCID: https://orcid.org/0000-0002-4599-7727, Kriek, N., Little, G., Sowa, M. A., Sage, T., Johnson, L. J. ORCID: https://orcid.org/0000-0002-0006-1511, Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154 (2022) Fully automated platelet differential interference contrast image analysis via deep learning. Scientific Reports, 12. 4614. ISSN 2045-2322 doi: 10.1038/s41598-022-08613-2

Dunster, J. ORCID: https://orcid.org/0000-0001-8986-4902, Bye, A. ORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Mitchell, J., Kempster, C., Batista, J., KcKinney, H., Thomas, P., Jones, C. ORCID: https://orcid.org/0000-0001-7537-1509, Downes, K., Unsworth, A. and Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances, 5 (20). pp. 4017-4030. ISSN 2473-9529 doi: 10.1182/bloodadvances.2020003261

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Unsworth, A. J., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Gaspar, R. S., Eaton, N., Drew, C., Stainer, A., Kriek, N., Volberding, P. J., Hutchinson, J. L., Riley, R., Jones, S., Mundell, S. J., Cui, W., Falet, H. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. Haematologica, 106 (7). ISSN 1592-8721 doi: 10.3324/haematol.2019.223529

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Sahli, K. A., Flora, G. D., Sasikumar, P., Maghrabi, A. H., Holbrook, L., AlOuda, S. K., Elgheznawy, A., Sage, T., Stainer, A. R., Adiyaman, R., AboHassan, M., Crescente, M., Kriek, N., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Structural, functional and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood, 137 (6). pp. 830-843. ISSN 0006-4971 doi: 10.1182/blood.2019004575

Gaspar, R. S., Unsworth, A. J., Al-Dibouni, A., Bye, A. P., Sage, T., Stewart, M., Cox, R. D., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Sellayah, D. and Hughes, C. ORCID: https://orcid.org/0000-0002-9790-5820 (2021) Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific Reports, 11. 1473. ISSN 2045-2322 doi: 10.1038/s41598-020-80373-3

Dunster, J. L. ORCID: https://orcid.org/0000-0001-8986-4902, Unsworth, A. J., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Haining, E. J.,, Sowa, M. A., Di, Y., Sage, T., Pallini, C., Pike, J. A., Hardy, A. T., Nieswandt, B., García, Á., Watson, S. P., Poulter, N. S., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154 (2020) Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. Journal of Thrombosis and Haemostasis, 18 (2). pp. 485-496. ISSN 1538-7836 doi: 10.1111/jth.14673

Flora, G. D., Sahli, K. A., Sasikumar, P., Holbrook, L.-M., Stainer, A. R., Alouda, S. K., Crescente, M., Sage, T., Unsworth, A. J. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2019) Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Scientific Reports, 9 (1). 17210. ISSN 2045-2322 doi: 10.1038/s41598-019-53218-x

Unsworth, A. J., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Osborne, A. A., Donaghy, D. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2019) Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets, 30 (6). pp. 762-772. ISSN 0953-7104 doi: 10.1080/09537104.2018.1514107

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Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Desborough, M. J., Hildyard, C. A. T., Appleby, N., Bruce, D., Kriek, N., Nock, S. H., Sage, T., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances, 1 (26). pp. 2610-2623. ISSN 2473-9529 doi: 10.1182/bloodadvances.2017011999

Unsworth, A. J., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Tannetta, D. S., Desborough, M. J. R., Kriek, N., Sage, T., Allan, H. E., Crescente, M., Yaqoob, P. ORCID: https://orcid.org/0000-0002-6716-7599, Warner, T. D., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2017) Farnesoid X receptor and liver X receptor ligands initiate formation of coated platelets. Arteriosclerosis, thrombosis, and vascular biology, 37 (8). pp. 1482-1493. ISSN 1524-4636 doi: 10.1161/ATVBAHA.117.309135

Unsworth, A. J., Flora, G. D., Sasikumar, P., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Kriek, N., Crescente, M. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2017) RXR ligands negatively regulate thrombosis and hemostasis. Arteriosclerosis Thrombosis and Vascular Biology, 37 (5). pp. 812-822. ISSN 1524-4636 doi: 10.1161/ATVBAHA.117.309207

Unsworth, A. J., Kriek, N., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Naran, K., Sage, T., Flora, G. D. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2017) PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and platelet function through upregulation of protein kinase A activity. Journal of Thrombosis and Haemostasis, 15 (2). pp. 356-369. ISSN 1538-7933 doi: 10.1111/jth.13578

Moraes, L. A., Unsworth, A. J., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Ali, M. S., Sasikumar, P., Sage, T., Flora, G. D., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Dorchies, E., Molendi-Coste, O., Dombrowicz, D., Staels, B., Bishop-Bailey, D. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2016) Farnesoid X Receptor and its ligands inhibit the function of platelets. Arteriosclerosis Thrombosis and Vascular Biology, 36 (12). pp. 2324-2333. ISSN 1524-4636 doi: 10.1161/ATVBAHA.116.308093

Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Sage, T., Rana, R. H., Schenk, M. P., Ali, M. S., Unsworth, A. J., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Stainer, A. R., Kriek, N. K., Moraes, L. A. and Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352 (2015) EphB2 regulates contact-dependent and independent signalling to control platelet function. Blood, 125 (4). pp. 720-730. ISSN 0006-4971 doi: 10.1182/blood-2014-06-585083

Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Sage, T., Moraes, L. A., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Hussain, U., Tucker, K. L., Barrett, N. E. ORCID: https://orcid.org/0000-0001-9123-1100 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2014) Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin αIIbβ3. Arteriosclerosis Thrombosis and Vascular Biology, 34 (9). pp. 1968-1976. ISSN 1079-5642 doi: 10.1161/ATVBAHA.114.304097

Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Tucker, K. L., Sasikumar, P., Sage, T., Kaiser, W. J., Moore, C., Emerson, M. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2014) Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi. Journal of Thrombosis and Haemostasis, 12 (8). pp. 1342-1352. ISSN 1538-7933 doi: 10.1111/jth.12620

Waller, A. K., Sage, T., Kumar, C., Carr, T., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Clarke, S. R. (2013) Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor. Journal of Infectious Diseases, 208 (12). pp. 2046-2057. ISSN 1537-6613 doi: 10.1093/infdis/jit398

Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Ali, M. S., Moraes, L. A., Sage, T., Lewis, K. R., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2013) Tangeretin regulates platelet function through inhibition of phosphoinositide 3-Kinase and cyclic nucleotide signaling. Arteriosclerosis Thrombosis and Vascular Biology, 33 (12). pp. 2740-2749. ISSN 1079-5642 doi: 10.1161/ATVBAHA.113.301988

Moraes, L. A., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Sasikumar, P., Ali, M. S., Kriek, N. K., Sage, T. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2013) Antithrombotic actions of statins involve PECAM-1 signalling. Blood, 122 (18). pp. 3188-3196. ISSN 0006-4971 doi: 10.1182/blood-2013-04-491845

Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Moraes, L. A., Sage, T., Ali, M. S., Lewis, K. R., Mayhaut-Smith, M. P., Oviedo-Orta, E., Simon, A. M. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2013) Connexin40 regulates platelet function. Nature Communications, 4. pp. 2564-2572. ISSN 2041-1723 doi: 10.1038/ncomms3564

Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Sasikumar, P., Moraes, L. A., Munger, S. J., Wright, J. R., Ali, M. S., Sage, T., Kaiser, W. J., Tucker, K. L., Stain, C. J., Bye, A. P., Jones, S., Oviedo-Orta, E., Simon, A. M., Mahaut-Smith, M. P. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2012) Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation, 125 (20). pp. 2479-2491. ISSN 0009-7322 doi: 10.1161/CIRCULATIONAHA.112.101246

Spyridon, M., Moraes, L. A., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Sage, T., Sasikumar, P., Bucci, G. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2011) LXR as a novel antithrombotic target. Blood, 117 (21). pp. 5751-5761. ISSN 1528-0020 doi: 10.1182/blood-2010-09-306142

Moraes, L. A., Barrett, N. E. ORCID: https://orcid.org/0000-0001-9123-1100, Jones, C. ORCID: https://orcid.org/0000-0001-7537-1509, Holbrook, L. M., Spyridon, M., Sage, T., Newman, D. K. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2010) Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells. Journal of Thrombosis and Haemostasis, 8 (11). pp. 2530-2541. ISSN 1538-7933 doi: 10.1111/j.1538-7836.2010.04025.x

Moraes, L. A., Spyridon, M., Kaiser, W. J., Jones, C. ORCID: https://orcid.org/0000-0001-7537-1509, Sage, T., Atherton, R. E. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2010) Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation. Journal of Thrombosis and Haemostasis, 8 (3). pp. 577-587. ISSN 1538-7933 doi: 10.1111/j.1538-7836.2009.03732.x

Cicmil, M., Thomas, J. M., Sage, T., Barry, F. A., Leduc, M., Bon, C. and Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352 (2000) Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases. The Journal of biological chemistry, 275 (35). pp. 27339-27347. ISSN 0021-9258 doi: 10.1074/jbc.M003196200

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Tucker, K. L., Sage, T. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2011) Clot retraction. In: Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Mahaut-Smith, M. P. (eds.) Platelets and Megakaryocytes. vol. 3, Additional Protocols and Perspectives. Methods in Molecular Biology, vol. 788. Humana Press, pp. 101-108. ISBN 9781617793066